Mouse Ccdc134 ELISA Kit (V2LY-0626-LY2195)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.054 ng/mL
Detection Range
0.1-38 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Mouse
Assay Type
Sandwich
Reactivity
Mouse
Assay Time
1.5 h
Molecule Mass
26.5 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
Coiled-Coil Domain Containing 134
Function
In extracellular secreted form, promotes proliferation and activation of CD8+ T cells, suggesting a cytokine-like function (PubMed:25125657).
Enhances cytotoxic anti-tumor activity of CD8+ T cells (PubMed:25125657).
May inhibit ERK and JNK signaling activity (PubMed:18087676, PubMed:23070808).
May suppress cell migration and invasion activity, via its effects on ERK and JNK signaling (PubMed:23070808).
In the nucleus, enhances stability of the PCAF histone acetyltransferase (HAT) complex member TADA2A and thus promotes PCAF-mediated H3K14 and H4K8 HAT activity. May inhibit TADA2A-mediated TP53/p53 'Lys-321' acetylation, leading to reduced TP53 stability and transcriptional activity. May also promote TADA2A-mediated XRCC6 acetylation thus facilitating cell apoptosis in response to DNA damage.
Biological Process
Angiogenesis Source: Ensembl
Embryonic hemopoiesis Source: Ensembl
Embryonic liver development Source: Ensembl
Placenta development Source: Ensembl
Ventricular system development Source: Ensembl
Cellular Location
Endoplasmic reticulum; Cytoplasm; Secreted; Nucleus. Accumulates in the nucleus in response to UV irradiation (PubMed:22644376).
PTM
O-glycosylated, with additional sialic acid modifications.

Yin, S., Liao, Q., Wang, Y., Shi, Q., Xia, P., Yi, M., & Huang, J. (2021). Ccdc134 deficiency impairs cerebellar development and motor coordination. Genes, Brain and Behavior, 20(7), e12763.

Holick, M. F., Shirvani, A., & Charoenngam, N. (2021). Fetal Fractures in an Infant with Maternal Ehlers-Danlos Syndrome, CCDC134 Pathogenic Mutation and a Negative Genetic Test for Osteogenesis Imperfecta. Children, 8(6), 512.

Dubail, J., Brunelle, P., Baujat, G., Huber, C., Doyard, M., Michot, C., ... & Cormier‐Daire, V. (2020). Homozygous loss‐of‐function mutations in CCDC134 are responsible for a severe form of osteogenesis imperfecta. Journal of Bone and Mineral Research, 35(8), 1470-1480.

Xia, P., Gong, X., Xiao, L., Wang, Y., Zhang, T., Liao, Q., ... & Huang, J. (2018). CCDC134 ameliorated experimental autoimmune encephalomyelitis by suppressing Th1 and Th17 cells. Brain, behavior, and immunity, 71, 158-168.

Yu, B., Zhang, T., Xia, P., Gong, X., Qiu, X., & Huang, J. (2018). CCDC134 serves a crucial role in embryonic development. International journal of molecular medicine, 41(1), 381-390.

Xia, P., Zhang, T., Gong, X., Xiao, L., Liao, Q., Qiu, X., & Huang, J. (2017). Amelioration of adjuvant-induced arthritis in CCDC134-overexpressing transgenic mice. Biochemical and biophysical research communications, 490(2), 111-116.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant CCDC134 protein, His Tag (CAT#: V2LY-0526-LY2619)

Human CCDC134 ELISA Kit (CAT#: V2LY-0626-LY4418)

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Mouse Anti-CCDC134 Recombinant Antibody (CBYY-C1049) (CAT#: CBMAB-C2486-YY)

Human Recombinant CCDC134 protein, His Tag (CAT#: V2LY-0526-LY2619)

Mouse Anti-CCDC134 Recombinant Antibody (CBYY-C0670) (CAT#: CBMAB-C1984-YY)

Rat Anti-CCDC134 Recombinant Antibody (815606) (CAT#: CBMAB-C8939-LY)

Human CCDC134 ELISA Kit (CAT#: V2LY-0626-LY4418)

Rabbit Anti-CCDC134 Recombinant Antibody (026) (CAT#: CBMAB-C1688-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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