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Rabbit Anti-CD247 Recombinant Antibody (CBYJT-1087) (CBMAB-T0097-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to CD247 (CD247 Molecule). The antibody can be used for immunoassay techniques, such as FC, IF, ICC.
See all CD247 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYJT-1087
Antibody Isotype
IgG
Application
FC, IF, ICC

Basic Information

Immunogen
A synthesized peptide derived from human CD3 zeta
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, 150 mM NaCl, pH 7.4, 50% Glycerol
Preservative
0.02% Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD247 Molecule
Introduction
CD247 (CD247 Molecule) is a Protein Coding gene. Diseases related to CD247 include Immunodeficiency 25 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta. Among its related pathways are G-protein signaling N-RAS regulation pathway and Role of phospholipids in phagocytosis. Gene Ontology (GO) annotations related to CD247 include protein homodimerization activity and transmembrane signaling receptor activity.
Entrez Gene ID
919
UniProt ID
P20963
Alternative Names
CD247 Molecule; CD3z Antigen, Zeta Polypeptide (TiT3 Complex); T-Cell Receptor T3 Zeta Chain; CD247 Antigen; CD3Z; TCRZ; T3Z; T-Cell Antigen Receptor Complex, Zeta Subunit Of CD3; T-Cell Surface Glycoprotein CD3 Zeta Chain
Function
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098, PubMed:7509083).
CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:7509083).
Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Peptide cross-linking Source: Reactome
Positive regulation of protein localization to cell surface Source: Ensembl
Regulation of defense response to virus by virus Source: Reactome
Regulation of immune response Source: Reactome
T cell receptor signaling pathway Source: GO_Central
Cellular Location
Cell membrane
Involvement in disease
Immunodeficiency 25 (IMD25): An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.
Topology
Extracellular: 22-30
Helical: 31-51
Cytoplasmic: 52-164
PTM
Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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