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CD247

CD247 (CD247 Molecule) is a Protein Coding gene. Diseases associated with CD247 include Immunodeficiency 25 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta. Among its related pathways are G-protein signaling N-RAS regulation pathway and Role of phospholipids in phagocytosis. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transmembrane signaling receptor activity.

Full Name

CD247 Molecule

Function

Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098, PubMed:7509083).
CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:7509083).
Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity).

Biological Process

Adaptive immune response Source: UniProtKB-KW
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Peptide cross-linking Source: Reactome
Positive regulation of protein localization to cell surface Source: Ensembl
Regulation of defense response to virus by virus Source: Reactome
Regulation of immune response Source: Reactome
T cell receptor signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Involvement in disease

Immunodeficiency 25 (IMD25): An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.

Topology

Extracellular: 22-30
Helical: 31-51
Cytoplasmic: 52-164

PTM

Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.

Anti-CD247 antibodies

Rabbit Anti-CD247 Recombinant Antibody (CBYJT-1087) (CBMAB-T0097-YJ)

SDS

Target: CD247

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-1087

Application*: F, IF, IC

Rat Anti-CD247 Recombinant Antibody (17A2) (CBMAB-C0429-LY)

SDS

Target: CD247

Host: Rat

Antibody Isotype: IgG2b, κ

Specificity: Mouse

Clone: 17A2

Application*: C, FN, C

Mouse Anti-CD247 Recombinant Antibody (1F4) (CBMAB-C0521-LY)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgM, κ

Specificity: Rat

Clone: 1F4

Application*: F

Mouse Anti-CD247 Recombinant Antibody (3H2012) (CBMAB-C1221-LY)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Mouse, Human

Clone: 3H2012

Application*: E, F, IH, IP, WB

Mouse Anti-CD247 Recombinant Antibody (CBXC-2989) (CBMAB-C4646-CQ)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-2989

Application*: WB, IS

Mouse Anti-CD247 Recombinant Antibody (CBXC-0199) (CBMAB-C4645-CQ)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0199

Application*: E, FN, IP, WB

Mouse Anti-CD247 Recombinant Antibody (CBYY-C0165) (CBMAB-C0517-YY)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Mouse

Clone: CBYY-C0165

Application*: E, F, IH, IP, WB

Mouse Anti-CD247 Recombinant Antibody (CBXC-0197) (CBMAB-C4644-CQ)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBXC-0197

Application*: E, IP, WB

Mouse Anti-CD247 Recombinant Antibody (CBXC-0198) (CBMAB-C4643-CQ)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXC-0198

Application*: F

Mouse Anti-CD247 (phosphorylated Tyr153) Recombinant Antibody (EM-17) (PTM-CBMAB-R4116-CN)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: EM-17

Application*: WB, F

Mouse Anti-CD247 (phosphorylated Tyr142) Recombinant Antibody (EM-54) (PTM-CBMAB-R4117-CN)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: EM-54

Application*: WB, F

Mouse Anti-CD247 (phosphorylated Tyr111) Recombinant Antibody (EM-55) (PTM-CBMAB-R4118-CN)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: EM-55

Application*: WB, F

Mouse Anti-CD247 Recombinant Antibody (CBXC-0196) (CBMAB-C4641-CQ)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXC-0196

Application*: E, F, IF, P, WB

Mouse Anti-CD247 Recombinant Antibody (G3) (CBMAB-C4640-CQ)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: G3

Application*: E, F, C, IP, WB

Armenian Hamster Anti-CD247 Recombinant Antibody (H146-968) (CBMAB-C0681-CQ)

SDS

Target: CD247

Host: Armenian Hamster

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: H146-968

Application*: WB, F, IF

Rabbit Anti-CD247 Recombinant Antibody (CB-336-1B2) (CBMAB-BT013LY)

SDS

Target: CD247

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CB-336-1B2

Application*: WB, IP, IHC, IHC-IF, F

Hamster Anti-CD247 Recombinant Antibody (A040) (CBMAB-AP12034LY)

SDS

Target: CD247

Host: Hamster

Antibody Isotype: IgG

Specificity: Mouse

Clone: A040

Application*: FC

Mouse Anti-CD247 Recombinant Antibody (CBFYC-0026) (CBMAB-C0033-FY)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBFYC-0026

Application*: E, IH

Mouse Anti-CD247 Recombinant Antibody (CBFYC-1176) (CBMAB-C1234-FY)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: CBFYC-1176

Application*: WB, IP

Mouse Anti-CD247 (AA 153-164) Recombinant Antibody (CBFYC-1177) (CBMAB-C1235-FY)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1177

Application*: WB

Mouse Anti-CD247 Recombinant Antibody (CBXC-2911) (CBMAB-C0231-CQ)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: CBXC-2911

Application*: F, E, IF

Mouse Anti-CD247 Recombinant Antibody (4A12-F6) (CBMAB-C1369-LY)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4A12-F6

Application*: E, IH, IP, WB

Mouse Anti-CD247 Recombinant Antibody (4D10A6) (CBMAB-C1682-LY)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 4D10A6

Application*: F, E

Mouse Anti-CD247 Recombinant Antibody (13B121) (CBMAB-C2777-LY)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 13B121

Application*: E, F, C, WB

Mouse Anti-CD247 Recombinant Antibody (13B123) (CBMAB-C2779-LY)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 13B123

Application*: E, IH

Mouse Anti-CD247 Recombinant Antibody (1D4) (CBMAB-C3826-LY)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1D4

Application*: WB

Mouse Anti-CD247 Recombinant Antibody (4B10) (CBMAB-C6627-LY)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 4B10

Application*: E, WB, P, IF/C, F

Mouse Anti-CD247 Recombinant Antibody (6B10) (CBMAB-C8074-LY)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: 6B10

Application*: E, IP, WB

Mouse Anti-CD247 Recombinant Antibody (6B10.2) (CBMAB-C1583-YY)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 6B10.2

Application*: WB, IP, IF, P, F

Mouse Anti-CD247 Recombinant Antibody (CBYY-C1280) (CBMAB-C2718-YY)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse

Clone: CBYY-C1280

Application*: E, IP, WB

Mouse Anti-CD247 Recombinant Antibody (WT32) (CBMAB-C10130-LY)

SDS

Target: CD247

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: WT32

Application*: FN, IF

Rat Anti-CD247 Recombinant Antibody (3B19) (CBMAB-C10127-LY)

SDS

Target: CD247

Host: Rat

Antibody Isotype: IgG2b

Specificity: Mouse

Clone: 3B19

Application*: IH

Rabbit Anti-CD247 Recombinant Antibody (MRQ-39) (CBMAB-C10129-LY)

SDS

Target: CD247

Host: Rabbit

Antibody Isotype: IgG1

Specificity: Human

Clone: MRQ-39

Application*: P, C

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)

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