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CD247

CD247 (CD247 Molecule) is a Protein Coding gene. Diseases associated with CD247 include Immunodeficiency 25 and T-B+ Severe Combined Immunodeficiency Due To Cd3delta/Cd3epsilon/Cd3zeta. Among its related pathways are G-protein signaling N-RAS regulation pathway and Role of phospholipids in phagocytosis. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and transmembrane signaling receptor activity.
Full Name
CD247 Molecule
Function
Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways (PubMed:2470098, PubMed:7509083).
CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:7509083).
Plays an important role in intrathymic T-cell differentiation. Additionally, participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity).
Biological Process
Adaptive immune response Source: UniProtKB-KW
Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
Negative regulation of inflammatory response to antigenic stimulus Source: Reactome
Peptide cross-linking Source: Reactome
Positive regulation of protein localization to cell surface Source: Ensembl
Regulation of defense response to virus by virus Source: Reactome
Regulation of immune response Source: Reactome
T cell receptor signaling pathway Source: GO_Central
Cellular Location
Cell membrane
Involvement in disease
Immunodeficiency 25 (IMD25): An immunological deficiency characterized by T-cells impaired immune response to alloantigens, tetanus toxoid and mitogens.
Topology
Extracellular: 22-30
Helical: 31-51
Cytoplasmic: 52-164
PTM
Phosphorylated on Tyr residues after T-cell receptor triggering by LCK in association with CD4/CD8.
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Anti-CD247 antibodies

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Mouse Anti-CD247 Recombinant Antibody (6B10.2) (CBMAB-C1583-YY)

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Target: CD247
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 6B10.2
Application*: WB, IP, P, F, IF
Datasheet SDS

Mouse Anti-CD247 Recombinant Antibody (CBT291) (V2LY-0625-LY3628)

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Target: CD247
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT291
Application*: WB, P, IF, IC, F, E
Datasheet SDS

Mouse Anti-CD247 Recombinant Antibody (CBT294) (V2LY-0625-LY3625)

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Target: CD247
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT294
Application*: F, E
Datasheet SDS

Mouse Anti-CD247 Recombinant Antibody (CBT295) (V2LY-0625-LY3624)

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Target: CD247
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT295
Application*: IF, IC, E
Datasheet SDS

Mouse Anti-CD247 Recombinant Antibody (CBT4450) (V2LY-0625-LY2418)

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Target: CD247
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4450
Application*: IH, IC, F
Datasheet SDS

Mouse Anti-CD247 (phosphorylated Tyr92) Recombinant Antibody (EM-26) (PTM-CBMAB-R4118-CN)

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Target: CD247
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: EM-26
Application*: WB, F, IF
Datasheet SDS

Mouse Anti-CD247 (phosphorylated Tyr142) Recombinant Antibody (EM-54) (PTM-CBMAB-R4117-CN)

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Target: CD247
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: EM-54
Application*: WB, F
Datasheet SDS

Mouse Anti-CD247 (phosphorylated Tyr153) Recombinant Antibody (EM-17) (PTM-CBMAB-R4116-CN)

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Target: CD247
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: EM-17
Application*: WB, F
Datasheet SDS

Armenian Hamster Anti-CD247 Recombinant Antibody (H146-968) (CBMAB-C0681-CQ)

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Target: CD247
Host: Armenian Hamster
Antibody Isotype: IgG2
Specificity: Human, Mouse, Rat
Clone: H146-968
Application*: WB, IP, E, IF, F
Datasheet SDS

Mouse Anti-CD247 Recombinant Antibody (CBXC-2911) (CBMAB-C0231-CQ)

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Target: CD247
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXC-2911
Application*: F
Datasheet SDS

Mouse Anti-CD247 Recombinant Antibody (CBYY-C1280) (CBMAB-C2718-YY)

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Target: CD247
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human, Mouse, Rat, Cattle, Dog, Pig
Clone: CBYY-C1280
Application*: WB, IP, E, IF
Datasheet SDS

Mouse Anti-CD247 Recombinant Antibody (CBYY-C0165) (CBMAB-C0517-YY)

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Target: CD247
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBYY-C0165
Application*: WB, IP, E, IF, P
Datasheet SDS

Rabbit Anti-CD247 Recombinant Antibody (CBYJT-1087) (CBMAB-T0097-YJ)

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Target: CD247
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBYJT-1087
Application*: WB, E
Datasheet SDS

Mouse Anti-CD247 Recombinant Antibody (CBFYC-1177) (CBMAB-C1235-FY)

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Target: CD247
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1177
Application*: WB, IP, P, F, IF
Datasheet SDS

Mouse Anti-CD247 Recombinant Antibody (CBFYC-1176) (CBMAB-C1234-FY)

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Target: CD247
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat, Cattle, Dog, Pig
Clone: CBFYC-1176
Application*: WB, IP, E, IF
Datasheet SDS

Mouse Anti-CD247 Recombinant Antibody (CBFYC-0026) (CBMAB-C0033-FY)

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Target: CD247
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYC-0026
Application*: WB, IP, E, F
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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