Sign in or Register   Sign in or Register
  |  

Mouse Anti-CD52 Recombinant Antibody (HI186) (CBMAB-C0703-CQ)

This product is a mouse antibody that recognizes CD52. The antibody HI186 can be used for immunoassay techniques such as: FC, IHC, IHC-P.
See all CD52 antibodies
Published Data
Fig.1 Histological sections of the colon from the each group three weeks after the anti-CD52 treatment.
...View More
Fig.2 The depletion of CD4+ T cells among colon lamina propria mononuclear cells (LPMCs) three weeks after the anti-CD52 treatment.
...View More

Summary

Host Animal
Mouse
Specificity
Human
Clone
HI186
Antibody Isotype
IgG2b
Application
FC, IHC, IHC-P

Basic Information

Immunogen
Human tonisl (NM_001803.2)
Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CD52 Molecule
Introduction
CD52 (CD52 Molecule) is a Protein Coding gene. Diseases associated with CD52 include Relapsing-Remitting Multiple Sclerosis and Leukemia, Chronic Lymphocytic. Among its related pathways are Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.
Entrez Gene ID
1043
UniProt ID
P31358
Alternative Names
CD52 Molecule; Human Epididymis-Specific Protein 5; CD52 Antigen (CAMPATH-1 Antigen); Epididymal Secretory Protein E5; Cambridge Pathology 1 Antigen; CDW52; He5;
Function
May play a role in carrying and orienting carbohydrate, as well as having a more specific role.
Biological Process
Positive regulation of cytosolic calcium ion concentration Source: UniProtKB
Respiratory burst Source: UniProtKB
Cellular Location
Cell membrane

Frota, N. F., de Sousa Rebouças, A., Fuzo, C. A., & Lourenzoni, M. R. (2021). Alemtuzumab scFv fragments and CD52 interaction study through molecular dynamics simulation and binding free energy. Journal of Molecular Graphics and Modelling, 107949.

Mao, R., Yang, F., Zhang, Y., Liu, H., Guo, P., Liu, Y., & Zhang, T. (2021). High expression of CD52 in adipocytes: a potential therapeutic target for obesity with type 2 diabetes. Aging (Albany NY), 13(8), 11043.

Wang, J., Zhang, G., Sui, Y., Yang, Z., Chu, Y., Tang, H., ... & Wu, C. (2020). CD52 Is a Prognostic Biomarker and Associated With Tumor Microenvironment in Breast Cancer. Frontiers in Genetics, 11, 1350.

Bhamidipati, K., Silberstein, J. L., Chaichian, Y., Baker, M. C., Lanz, T. V., Zia, A., ... & Robinson, W. H. (2020). CD52 is Elevated on B cells of SLE Patients and Regulates B Cell Function. Frontiers in Immunology, 11, 3736.

Shathili, A. M., Bandala-Sanchez, E., John, A., Goddard-Borger, E. D., Thaysen-Andersen, M., Everest-Dass, A. V., ... & Packer, N. H. (2019). Specific sialoforms required for the immune suppressive activity of human soluble CD52. Frontiers in immunology, 10, 1967.

Zheng, C., Zhuang, C., Chen, Y., Fu, Q., Qian, H., Wang, Y., ... & Qi, N. (2018). Improved process robustness, product quality and biological efficacy of an anti-CD52 monoclonal antibody upon pH shift in Chinese hamster ovary cell perfusion culture. Process Biochemistry, 65, 123-129.

Simon, M., Ipek, R., Homola, G. A., Rovituso, D. M., Schampel, A., Kleinschnitz, C., & Kuerten, S. (2018). Anti-CD52 antibody treatment depletes B cell aggregates in the central nervous system in a mouse model of multiple sclerosis. Journal of neuroinflammation, 15(1), 1-15.

Rashidi, M., Bandala-Sanchez, E., Lawlor, K. E., Zhang, Y., Neale, A. M., Vijayaraj, S. L., ... & Harrison, L. C. (2018). CD52 inhibits Toll-like receptor activation of NF-κ B and triggers apoptosis to suppress inflammation. Cell Death & Differentiation, 25(2), 392-405.

Bandala-Sanchez, E., Bediaga, N. G., Goddard-Borger, E. D., Ngui, K., Naselli, G., Stone, N. L., ... & Harrison, L. C. (2018). CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function. Proceedings of the National Academy of Sciences, 115(30), 7783-7788.

Zhao, Y., Su, H., Shen, X., Du, J., Zhang, X., & Zhao, Y. (2017). The immunological function of CD52 and its targeting in organ transplantation. Inflammation Research, 66(7), 571-578.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CD52 Recombinant Antibody (HI186)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare