Sign in or Register   Sign in or Register
  |  

Mouse Anti-CES2 Recombinant Antibody (12K61) (CBMAB-C2246-CN)

This product is a Mouse antibody that recognizes CES2. The antibody 12K61 can be used for immunoassay techniques such as: IF, IP, WB.
See all CES2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
12K61
Antibody Isotype
IgG1
Application
IF, IP, WB

Basic Information

Immunogen
Recombinant corresponding to aa 27-559 from human CES2 expressed in NSO cell line
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
PBS, trehalose. Reconstitute with sterile PBS to 0.5 mg/mL
Concentration
0.5 mg/mL (after reconstitution)

Target

Full Name
Ceramide Synthase 2
Introduction
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
Entrez Gene ID
8824
UniProt ID
O00748
Alternative Names
Carboxylesterase 2; Methylumbelliferyl-Acetate Deacetylase 2; Carboxylesterase 2 (Intestine, Liver); EC 3.1.1.1; HCE-2; CE-2; ICE; Intestinal Carboxylesterase; Liver Carboxylesterase-2;
Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443).
Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443).
Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105).
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984).
Biological Process
Catabolic process Source: ProtInc
Lipid catabolic process Source: GO_Central
Prostaglandin metabolic process Source: BHF-UCL
Xenobiotic metabolic process Source: Reactome
Cellular Location
Endoplasmic reticulum lumen
PTM
Glycosylated.

Xu, Y., Pan, X., Hu, S., Zhu, Y., Cassim Bawa, F., Li, Y., ... & Zhang, Y. (2021). Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice. American Journal of Physiology-Gastrointestinal and Liver Physiology, 320(2), G166-G174.

Shen, Y., Eades, W., & Yan, B. (2021). Remdesivir potently inhibits carboxylesterase‐2 through covalent modifications: signifying strong drug‐drug interactions. Fundamental & Clinical Pharmacology, 35(2), 432-434.

Chalhoub, G., Kolleritsch, S., Maresch, L. K., Taschler, U., Pajed, L., Tilp, A., ... & Haemmerle, G. (2021). Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease. Journal of lipid research, 62.

Song, Y. Q., He, R. J., Pu, D., Guan, X. Q., Shi, J. H., Li, Y. G., ... & Ge, G. B. (2021). Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2. Frontiers in pharmacology, 12.

Qian, X. K., Zhang, J., Song, P. F., Zhao, Y. S., Ma, H. Y., Jin, Q., ... & Zou, L. W. (2021). Discovery of pyrazolones as novel carboxylesterase 2 inhibitors that potently inhibit the adipogenesis in cells. Bioorganic & Medicinal Chemistry, 40, 116187.

Tian, X., Yan, F., Zheng, J., Cui, X., Feng, L., Li, S., ... & Ma, X. (2019). Endoplasmic reticulum targeting ratiometric fluorescent probe for carboxylesterase 2 detection in drug-induced acute liver injury. Analytical chemistry, 91(24), 15840-15845.

Yi, J., Bai, R., An, Y., Liu, T. T., Liang, J. H., Tian, X. G., ... & Zhang, H. L. (2019). A natural inhibitor from Alisma orientale against human carboxylesterase 2: kinetics, circular dichroism spectroscopic analysis, and docking simulation. International journal of biological macromolecules, 133, 184-189.

Zhao, Y. S., Ruan, H. L., Wang, X. Y., Chen, C., Song, P. F., Lü, C. W., & Zou, L. W. (2019). Catalyst-free visible-light-induced condensation to synthesize bis (indolyl) methanes and biological activity evaluation of them as potent human carboxylesterase 2 inhibitors. RSC Advances, 9(68), 40168-40175.

Ruby, M. A., Massart, J., Hunerdosse, D. M., Schönke, M., Correia, J. C., Louie, S. M., ... & Zierath, J. R. (2017). Human carboxylesterase 2 reverses obesity-induced diacylglycerol accumulation and glucose intolerance. Cell reports, 18(3), 636-646.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-CES2 Recombinant Antibody (12K61)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare