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CES2

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Full Name
Ceramide Synthase 2
Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443).
Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443).
Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105).
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984).
Biological Process
Catabolic process Source: ProtInc
Lipid catabolic process Source: GO_Central
Prostaglandin metabolic process Source: BHF-UCL
Xenobiotic metabolic process Source: Reactome
Cellular Location
Endoplasmic reticulum lumen
PTM
Glycosylated.

Anti-CES2 antibodies

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Target: CES2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYC-1734
Application*: E, WB
Target: CES2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1733
Application*: IC, IP, WB
Target: CES2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG656
Application*: WB: 1:500~1:1000 ELISA: 1:40000
Target: CES2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 12K61
Application*: IF, IP, WB
Target: CES2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 720711
Application*: WB, IP, IC
Target: CES2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4F12
Application*: E, WB, P, IP
Target: CES2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D4B
Application*: IC, IP, WB
Target: CES2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 10B2209
Application*: E, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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