CES2

This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Full Name
Ceramide Synthase 2
Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443).
Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443).
Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105).
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984).
Biological Process
Catabolic process Source: ProtInc
Lipid catabolic process Source: GO_Central
Prostaglandin metabolic process Source: BHF-UCL
Xenobiotic metabolic process Source: Reactome
Cellular Location
Endoplasmic reticulum lumen
PTM
Glycosylated.
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Anti-CES2 antibodies

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Rabbit Anti-CES2 Recombinant Antibody (EG656) (CBMAB-EN791-LY)

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Target: CES2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG656
Application*: IF, WB
Datasheet SDS

Mouse Anti-CES2 Recombinant Antibody (C2246) (CBMAB-C2246-CN)

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Target: CES2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: C2246
Application*: E, WB
Datasheet SDS

Mouse Anti-CES2 Recombinant Antibody (CBFYC-1734) (CBMAB-C1796-FY)

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Target: CES2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1734
Application*: IF, WB
Datasheet SDS

Mouse Anti-CES2 Recombinant Antibody (CBFYC-1733) (CBMAB-C1795-FY)

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Target: CES2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYC-1733
Application*: IC, IP, WB
Datasheet SDS

Mouse Anti-CES2 Recombinant Antibody (4F12) (CBMAB-C6915-LY)

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Target: CES2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4F12
Application*: E, WB, IH
Datasheet SDS

Mouse Anti-CES2 Recombinant Antibody (C2164) (CBMAB-C2164-LY)

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Target: CES2
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: C2164
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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