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Rabbit Anti-CES2 Recombinant Antibody (EG656) (CBMAB-EN791-LY)


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Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG656
Antibody Isotype
IgG
Application
IF, WB

Basic Information

Immunogen
A synthesized peptide derived from human CES1.
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:500-1:2,000
IF(ICC)1:50-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.05% BSA, 50% Glycerol
Preservative
0.02% sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ceramide Synthase 2
Introduction
This gene encodes a protein that has sequence similarity to yeast longevity assurance gene 1. Mutation or overexpression of the related gene in yeast has been shown to alter yeast lifespan. The human protein may play a role in the regulation of cell growth. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Entrez Gene ID
29956
UniProt ID
Q96G23
Alternative Names
Ceramide Synthase 2; Longevity Assurance (LAG1, S. Cerevisiae) Homolog 2; Tumor Metastasis-Suppressor Gene 1 Protein; LAG1 Homolog, Ceramide Synthase 2; LASS2; SP260; TMSG1;
Function
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443).
Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443).
Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105).
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984).
Biological Process
Catabolic process Source: ProtInc
Lipid catabolic process Source: GO_Central
Prostaglandin metabolic process Source: BHF-UCL
Xenobiotic metabolic process Source: Reactome
Cellular Location
Endoplasmic reticulum lumen
PTM
Glycosylated.
More Infomation

Xu, Y., Pan, X., Hu, S., Zhu, Y., Cassim Bawa, F., Li, Y., ... & Zhang, Y. (2021). Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice. American Journal of Physiology-Gastrointestinal and Liver Physiology, 320(2), G166-G174.

Shen, Y., Eades, W., & Yan, B. (2021). Remdesivir potently inhibits carboxylesterase‐2 through covalent modifications: signifying strong drug‐drug interactions. Fundamental & Clinical Pharmacology, 35(2), 432-434.

Chalhoub, G., Kolleritsch, S., Maresch, L. K., Taschler, U., Pajed, L., Tilp, A., ... & Haemmerle, G. (2021). Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease. Journal of lipid research, 62.

Song, Y. Q., He, R. J., Pu, D., Guan, X. Q., Shi, J. H., Li, Y. G., ... & Ge, G. B. (2021). Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2. Frontiers in pharmacology, 12.

Qian, X. K., Zhang, J., Song, P. F., Zhao, Y. S., Ma, H. Y., Jin, Q., ... & Zou, L. W. (2021). Discovery of pyrazolones as novel carboxylesterase 2 inhibitors that potently inhibit the adipogenesis in cells. Bioorganic & Medicinal Chemistry, 40, 116187.

Tian, X., Yan, F., Zheng, J., Cui, X., Feng, L., Li, S., ... & Ma, X. (2019). Endoplasmic reticulum targeting ratiometric fluorescent probe for carboxylesterase 2 detection in drug-induced acute liver injury. Analytical chemistry, 91(24), 15840-15845.

Yi, J., Bai, R., An, Y., Liu, T. T., Liang, J. H., Tian, X. G., ... & Zhang, H. L. (2019). A natural inhibitor from Alisma orientale against human carboxylesterase 2: kinetics, circular dichroism spectroscopic analysis, and docking simulation. International journal of biological macromolecules, 133, 184-189.

Zhao, Y. S., Ruan, H. L., Wang, X. Y., Chen, C., Song, P. F., Lü, C. W., & Zou, L. W. (2019). Catalyst-free visible-light-induced condensation to synthesize bis (indolyl) methanes and biological activity evaluation of them as potent human carboxylesterase 2 inhibitors. RSC Advances, 9(68), 40168-40175.

Ruby, M. A., Massart, J., Hunerdosse, D. M., Schönke, M., Correia, J. C., Louie, S. M., ... & Zierath, J. R. (2017). Human carboxylesterase 2 reverses obesity-induced diacylglycerol accumulation and glucose intolerance. Cell reports, 18(3), 636-646.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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