Human Recombinant CES2, Active protein, GST Tag (V2LY-0526-LY2570)

Name: Human Recombinant CES2, Active protein, GST Tag
SKU: V2LY-0526-LY2570
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

Baculovirus-Insect Cells

Protein Species

Human

Tag

GST Tag

Protein Construction

This product is Human Recombinant CES2, Active protein, GST Tag consist of Amino Acid: Full Length and predicts a molecular mass of 90 kDa.

Molecule Mass

90 kDa

Sequence

Amino Acid: Full Length

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

Batch dependent.

Endotoxin

Please contact us for more information.

Format

Liquid

Buffer

Tris, NaCl, Glutathione, EDTA, DTT, PMSF, Glycerol

Preservative

None

Storage

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.

More Infomation

Target

Full Name

Ceramide Synthase 2

Function

Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (PubMed:9169443).
Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine (PubMed:9169443).
Hydrolyzes aspirin, substrates with large alcohol group and small acyl group and endogenous lipids such as triacylglycerol (PubMed:28677105).
Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes of 2-arachidonoylglycerol and prostaglandins (PubMed:21049984).

Biological Process

Catabolic process Source: ProtInc
Lipid catabolic process Source: GO_Central
Prostaglandin metabolic process Source: BHF-UCL
Xenobiotic metabolic process Source: Reactome

Cellular Location

Endoplasmic reticulum lumen

PTM

Glycosylated.

Xu, Y., Pan, X., Hu, S., Zhu, Y., Cassim Bawa, F., Li, Y., ... & Zhang, Y. (2021). Hepatocyte-specific expression of human carboxylesterase 2 attenuates nonalcoholic steatohepatitis in mice. American Journal of Physiology-Gastrointestinal and Liver Physiology, 320(2), G166-G174.

Shen, Y., Eades, W., & Yan, B. (2021). Remdesivir potently inhibits carboxylesterase‐2 through covalent modifications: signifying strong drug‐drug interactions. Fundamental & Clinical Pharmacology, 35(2), 432-434.

Chalhoub, G., Kolleritsch, S., Maresch, L. K., Taschler, U., Pajed, L., Tilp, A., ... & Haemmerle, G. (2021). Carboxylesterase 2 proteins are efficient diglyceride and monoglyceride lipases possibly implicated in metabolic disease. Journal of lipid research, 62.

Song, Y. Q., He, R. J., Pu, D., Guan, X. Q., Shi, J. H., Li, Y. G., ... & Ge, G. B. (2021). Discovery and Characterization of the Biflavones From Ginkgo biloba as Highly Specific and Potent Inhibitors Against Human Carboxylesterase 2. Frontiers in pharmacology, 12.

Qian, X. K., Zhang, J., Song, P. F., Zhao, Y. S., Ma, H. Y., Jin, Q., ... & Zou, L. W. (2021). Discovery of pyrazolones as novel carboxylesterase 2 inhibitors that potently inhibit the adipogenesis in cells. Bioorganic & Medicinal Chemistry, 40, 116187.

Tian, X., Yan, F., Zheng, J., Cui, X., Feng, L., Li, S., ... & Ma, X. (2019). Endoplasmic reticulum targeting ratiometric fluorescent probe for carboxylesterase 2 detection in drug-induced acute liver injury. Analytical chemistry, 91(24), 15840-15845.

Yi, J., Bai, R., An, Y., Liu, T. T., Liang, J. H., Tian, X. G., ... & Zhang, H. L. (2019). A natural inhibitor from Alisma orientale against human carboxylesterase 2: kinetics, circular dichroism spectroscopic analysis, and docking simulation. International journal of biological macromolecules, 133, 184-189.

Zhao, Y. S., Ruan, H. L., Wang, X. Y., Chen, C., Song, P. F., Lü, C. W., & Zou, L. W. (2019). Catalyst-free visible-light-induced condensation to synthesize bis (indolyl) methanes and biological activity evaluation of them as potent human carboxylesterase 2 inhibitors. RSC Advances, 9(68), 40168-40175.

Ruby, M. A., Massart, J., Hunerdosse, D. M., Schönke, M., Correia, J. C., Louie, S. M., ... & Zierath, J. R. (2017). Human carboxylesterase 2 reverses obesity-induced diacylglycerol accumulation and glucose intolerance. Cell reports, 18(3), 636-646.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Mouse Recombinant CES2 protein, His Tag (CAT#: V2LY-0526-LY7913)

Human Recombinant CES2 protein, His Tag (CAT#: V2LY-0526-LY2571)

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Mouse Recombinant CES2 protein, His Tag (CAT#: V2LY-0526-LY7913)

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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