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Mouse Anti-DHX8 Recombinant Antibody (1D6) (CBMAB-A2221-LY)

The product is antibody recognizes DHX8. The antibody 1D6 immunoassay techniques such as: WB, ELISA.
See all DHX8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1D6
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
DHX8 (NP_004932, 301 a.a. ~ 400 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DEAH-Box Helicase 8
Introduction
DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is highly homologous to yeast Prp22. This protein facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome. [provided by RefSeq]
Entrez Gene ID
1659
UniProt ID
Q14562
Alternative Names
DDX8; HRH1; PRP22; PRPF22
Function
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346).

Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946).
Biological Process
mRNA splicing, via spliceosome Source: UniProtKB
RNA processing Source: ProtInc
RNA splicing Source: ProtInc
Spliceosomal complex disassembly Source: GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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