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Mouse Anti-DHX8 Recombinant Antibody (1E10) (CBMAB-D0862-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DEAH-Box Helicase 8 (DHX8). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all DHX8 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1E10
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DEAH-Box Helicase 8
Introduction
DHX8 is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1).
Entrez Gene ID
1659
UniProt ID
Q14562
Alternative Names
DEAH-Box Helicase 8; DEAD/H (Asp-Glu-Ala-Asp/His) Box Polypeptide 8 (RNA Helicase); DEAH (Asp-Glu-Ala-His) Box Polypeptide 8; DEAH Box Protein 8; RNA Helicase HRH1; DDX8; ATP-Dependent RNA Helicase DHX8;
Function
Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346).

Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946).
Biological Process
mRNA splicing, via spliceosome Source: UniProtKB
RNA processing Source: ProtInc
RNA splicing Source: ProtInc
Spliceosomal complex disassembly Source: GO_Central
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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