DHX8

This gene is a member of the DEAH box polypeptide family. The encoded protein contains the DEAH (Asp-Glu-Ala-His) motif which is characteristic of all DEAH box proteins, and is thought to function as an ATP-dependent RNA helicase that regulates the release of spliced mRNAs from spliceosomes prior to their export from the nucleus. This protein may be required for the replication of human immunodeficiency virus type 1 (HIV-1). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

DEAH-Box Helicase 8

Involved in pre-mRNA splicing as component of the spliceosome (PubMed:11991638, PubMed:28502770, PubMed:28076346).

Facilitates nuclear export of spliced mRNA by releasing the RNA from the spliceosome (PubMed:8608946).

mRNA splicing, via spliceosome Source: UniProtKB
RNA processing Source: ProtInc
RNA splicing Source: ProtInc
Spliceosomal complex disassembly Source: GO_Central

Nucleus