Mouse Anti-DNAJB4 Recombinant Antibody (1H2-3G4) (V2LY-0425-LY633)

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Basic Information

Host Animal
Mouse
Clone
1H2-3G4
Application
ELISA, WB
Immunogen
Full length recombinant DNAJB4.
Host Species
Mouse
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
DnaJ Heat Shock Protein Family (Hsp40) Member B4
Entrez Gene ID
Human11080
Mouse67035
Rat295549
UniProt ID
HumanQ9UDY4
MouseQ9D832
RatP33535
Function
Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).
Biological Process
Chaperone cofactor-dependent protein refolding Source: GO_Central
Response to heat Source: ProtInc
Response to unfolded protein Source: ProtInc
Cellular Location
Cytoplasm; Cell membrane. Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.

Topf, A., Bengoechea, R., Duff, J., Charlton, R., Mroczek, M., Garcia, S. K., ... & Straub, V. (2021). NEW GENES, NEW TECHNIQUES IN NEUROMUSCULAR DISORDERS: O. 10 Loss of function mutations in DNAJB4 cause a myopathy with early respiratory failure. Neuromuscular Disorders, 31, S160.

Mo, L., Liu, J., Yang, Z., Gong, X., Meng, F., Zou, R., ... & Fang, F. (2020). DNAJB4 identified as a potential breast cancer marker: evidence from bioinformatics analysis and basic experiments. Gland Surgery, 9(6), 1955.

Inoue, M., Iida, A., Watanabe, K., Hosoi, Y., Miyajima, H., Hayashi, S., ... & Nishino, I. (2020). NEW GENES IN NEUROMUSCULAR DISEASES: O. 02 A dominant variant in DNAJB4 causes myofibrillar myopathy. Neuromuscular Disorders, 30, S46.

Miao, W., Li, L., Zhao, Y., Dai, X., Chen, X., & Wang, Y. (2019). HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine. Nature communications, 10(1), 1-12.

Kagiali, Z. C. U., Sanal, E., Karayel, Ö., Polat, A. N., Saatci, Ö., Ersan, P. G., ... & Ozlu, N. (2019). Systems-level Analysis Reveals Multiple Modulators of Epithelial-mesenchymal Transition and Identifies DNAJB4 and CD81 as Novel Metastasis Inducers in Breast Cancer*[S]. Molecular & Cellular Proteomics, 18(9), 1756-1771.

Miao, W., Li, L., & Wang, Y. (2018). A targeted proteomic approach for heat shock proteins reveals DNAJB4 as a suppressor for melanoma metastasis. Analytical chemistry, 90(11), 6835-6842.

Acun, T., Doberstein, N., Habermann, J. K., Gemoll, T., Thorns, C., Oztas, E., & Ried, T. (2017). HLJ1 (DNAJB4) gene is a novel biomarker candidate in breast cancer. Omics: a journal of integrative biology, 21(5), 257-265.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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