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Rabbit Anti-DNAJB4 Recombinant Antibody (EG977) (CBMAB-EN1159-LY)

The product is antibody recognizes DNAJB4. The antibody EG977 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:40000.
See all DNAJB4 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EG977
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:40000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human DNAJB4.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
DnaJ Heat Shock Protein Family (Hsp40) Member B4
Introduction
The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Entrez Gene ID
Human11080
Mouse67035
Rat295549
UniProt ID
HumanQ9UDY4
MouseQ9D832
RatP33535
Alternative Names
DnaJ Heat Shock Protein Family (Hsp40) Member B4; DnaJ (Hsp40) Homolog, Subfamily B, Member 4; Heat Shock 40 KDa Protein 1 Homolog; Heat Shock Protein 40 Homolog; Human Liver DnaJ-Like Protein; HSP40 Homolog;
Function
Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).
Biological Process
Chaperone cofactor-dependent protein refolding Source: GO_Central
Response to heat Source: ProtInc
Response to unfolded protein Source: ProtInc
Cellular Location
Cytoplasm; Cell membrane. Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.

Topf, A., Bengoechea, R., Duff, J., Charlton, R., Mroczek, M., Garcia, S. K., ... & Straub, V. (2021). NEW GENES, NEW TECHNIQUES IN NEUROMUSCULAR DISORDERS: O. 10 Loss of function mutations in DNAJB4 cause a myopathy with early respiratory failure. Neuromuscular Disorders, 31, S160.

Mo, L., Liu, J., Yang, Z., Gong, X., Meng, F., Zou, R., ... & Fang, F. (2020). DNAJB4 identified as a potential breast cancer marker: evidence from bioinformatics analysis and basic experiments. Gland Surgery, 9(6), 1955.

Inoue, M., Iida, A., Watanabe, K., Hosoi, Y., Miyajima, H., Hayashi, S., ... & Nishino, I. (2020). NEW GENES IN NEUROMUSCULAR DISEASES: O. 02 A dominant variant in DNAJB4 causes myofibrillar myopathy. Neuromuscular Disorders, 30, S46.

Miao, W., Li, L., Zhao, Y., Dai, X., Chen, X., & Wang, Y. (2019). HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine. Nature communications, 10(1), 1-12.

Kagiali, Z. C. U., Sanal, E., Karayel, Ö., Polat, A. N., Saatci, Ö., Ersan, P. G., ... & Ozlu, N. (2019). Systems-level Analysis Reveals Multiple Modulators of Epithelial-mesenchymal Transition and Identifies DNAJB4 and CD81 as Novel Metastasis Inducers in Breast Cancer*[S]. Molecular & Cellular Proteomics, 18(9), 1756-1771.

Miao, W., Li, L., & Wang, Y. (2018). A targeted proteomic approach for heat shock proteins reveals DNAJB4 as a suppressor for melanoma metastasis. Analytical chemistry, 90(11), 6835-6842.

Acun, T., Doberstein, N., Habermann, J. K., Gemoll, T., Thorns, C., Oztas, E., & Ried, T. (2017). HLJ1 (DNAJB4) gene is a novel biomarker candidate in breast cancer. Omics: a journal of integrative biology, 21(5), 257-265.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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