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DNAJB4

The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Full Name

DnaJ Heat Shock Protein Family (Hsp40) Member B4

Function

Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).

Biological Process

Chaperone cofactor-dependent protein refolding Source: GO_Central
Response to heat Source: ProtInc
Response to unfolded protein Source: ProtInc

Cellular Location

Cytoplasm; Cell membrane. Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.

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Anti-DNAJB4 antibodies

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Mouse Anti-DNAJB4 Recombinant Antibody (EG977) (V2LY-0425-LY635)

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Target: DNAJB4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: EG977

Application*: E, IP, WB

Mouse Anti-DNAJB4 Recombinant Antibody (S13) (V2LY-0425-LY634)

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Target: DNAJB4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat

Clone: S13

Application*: E, IP, WB

Mouse Anti-DNAJB4 Recombinant Antibody (1H2-3G4) (V2LY-0425-LY633)

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Target: DNAJB4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: 1H2-3G4

Application*: E, WB

Rabbit Anti-DNAJB4 Recombinant Antibody (EG977) (CBMAB-EN1159-LY)

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Target: DNAJB4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG977

Application*: WB: 1:500~1:1000 ELISA: 1:40000

Mouse Anti-DNAJB4 Recombinant Antibody (S13) (CBMAB-D1293-YC)

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Target: DNAJB4

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: S13

Application*: E, IP, WB

Mouse Anti-DNAJB4 Recombinant Antibody (1H2-3G4) (CBMAB-D1292-YC)

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Target: DNAJB4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1H2-3G4

Application*: WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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