DNAJB4

The protein encoded by this gene is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The encoded protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

DnaJ Heat Shock Protein Family (Hsp40) Member B4

Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).

Chaperone cofactor-dependent protein refolding Source: GO_Central
Response to heat Source: ProtInc
Response to unfolded protein Source: ProtInc

Cytoplasm; Cell membrane. Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.