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Mouse Anti-DNAJB4 Recombinant Antibody (S13) (CBMAB-D1293-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DnaJ Heat Shock Protein Family (Hsp40) Member B4 (DNAJB4). The antibody can be used for immunoassay techniques, such as ELISA, IP, WB.
See all DNAJB4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
S13
Antibody Isotype
IgG2a, κ
Application
ELISA, IP, WB

Basic Information

Immunogen
DNAJB4 (AAH34721, 1 a.a. ~ 337 a.a) full-length recombinant protein with GST tag. The immunogen sequence: MGKDYYCILG IEKGASDEDI KKAYRKQALK FHPDKNKSPQ AEEKFKEVAE AYEVLSDPKK REIYDQFGEE GLKGGAGGTD GQGGTFRYTF HGDPHATFAA FFGGSNPFEI FFGRRMGGGR DSEEMEIDGD PFSAFGFSMN GYPRDRNSVG PSRLKQDPPV IHELRVSLEE IYSGCTKRMK ISRKRLNADG RSYRSEDKIL TIEIKKGWKE GTKITFPREG DETPNSIPAD IVFIIKDKDH PKFKRDGSNI IYTAKISLRE ALCGCSINVP TLDGRNIPMS VNDIVKPGMR RRIIGYGLPF PKNPDQRGDL LIEFEVSFPD TISSSSKEVL RKHLPAS
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-337

Target

Full Name
DnaJ Heat Shock Protein Family (Hsp40) Member B4
Introduction
DNAJB4 is a molecular chaperone, tumor suppressor, and member of the heat shock protein-40 family. The protein binds the cell adhesion protein E-cadherin and targets it to the plasma membrane. This protein also binds incorrectly folded E-cadherin and targets it for endoplasmic reticulum-associated degradation. This gene is a strong tumor suppressor for colorectal carcinoma, and downregulation of it may serve as a good biomarker for predicting patient outcomes.
Entrez Gene ID
11080
UniProt ID
Q9UDY4
Alternative Names
DnaJ Heat Shock Protein Family (Hsp40) Member B4; DnaJ (Hsp40) Homolog, Subfamily B, Member 4; Heat Shock 40 KDa Protein 1 Homolog; Heat Shock Protein 40 Homolog; Human Liver DnaJ-Like Protein; HSP40 Homolog;
Function
Probable chaperone. Stimulates ATP hydrolysis and the folding of unfolded proteins mediated by HSPA1A/B (in vitro) (PubMed:24318877).
Biological Process
Chaperone cofactor-dependent protein refolding Source: GO_Central
Response to heat Source: ProtInc
Response to unfolded protein Source: ProtInc
Cellular Location
Cytoplasm; Cell membrane. Cytoplasmic according to PubMed:18837411 and membrane-associated according to PubMed:16542645.

Topf, A., Bengoechea, R., Duff, J., Charlton, R., Mroczek, M., Garcia, S. K., ... & Straub, V. (2021). NEW GENES, NEW TECHNIQUES IN NEUROMUSCULAR DISORDERS: O. 10 Loss of function mutations in DNAJB4 cause a myopathy with early respiratory failure. Neuromuscular Disorders, 31, S160.

Mo, L., Liu, J., Yang, Z., Gong, X., Meng, F., Zou, R., ... & Fang, F. (2020). DNAJB4 identified as a potential breast cancer marker: evidence from bioinformatics analysis and basic experiments. Gland Surgery, 9(6), 1955.

Inoue, M., Iida, A., Watanabe, K., Hosoi, Y., Miyajima, H., Hayashi, S., ... & Nishino, I. (2020). NEW GENES IN NEUROMUSCULAR DISEASES: O. 02 A dominant variant in DNAJB4 causes myofibrillar myopathy. Neuromuscular Disorders, 30, S46.

Miao, W., Li, L., Zhao, Y., Dai, X., Chen, X., & Wang, Y. (2019). HSP90 inhibitors stimulate DNAJB4 protein expression through a mechanism involving N6-methyladenosine. Nature communications, 10(1), 1-12.

Kagiali, Z. C. U., Sanal, E., Karayel, Ö., Polat, A. N., Saatci, Ö., Ersan, P. G., ... & Ozlu, N. (2019). Systems-level Analysis Reveals Multiple Modulators of Epithelial-mesenchymal Transition and Identifies DNAJB4 and CD81 as Novel Metastasis Inducers in Breast Cancer*[S]. Molecular & Cellular Proteomics, 18(9), 1756-1771.

Miao, W., Li, L., & Wang, Y. (2018). A targeted proteomic approach for heat shock proteins reveals DNAJB4 as a suppressor for melanoma metastasis. Analytical chemistry, 90(11), 6835-6842.

Acun, T., Doberstein, N., Habermann, J. K., Gemoll, T., Thorns, C., Oztas, E., & Ried, T. (2017). HLJ1 (DNAJB4) gene is a novel biomarker candidate in breast cancer. Omics: a journal of integrative biology, 21(5), 257-265.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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