Mouse Anti-EBAG9 Monoclonal Antibody (5BA21) (CBMAB-1191CQ)

Name: Mouse Anti-EBAG9 Monoclonal Antibody (5BA21)
SKU: CBMAB-1191CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

5BA21

Application

ELISA, WB

Immunogen

Recombinant full length protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2c

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
ELISA	0.2-0.5 µg/ml
WB	0.2-0.5 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Preservative

None

Concentration

Batch dependent

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

estrogen receptor binding site associated antigen 9

Introduction

This gene was identified as an estrogen-responsive gene. The protein may participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. Diseases associated with EBAG9 include Placental Abruption and Bile Duct Carcinoma. Among its related pathways are Translational Control.

Entrez Gene ID

9166

UniProt ID

O00559

Alternative Names

EB9; PDAF

Research Area

May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases.

Biological Process

Regulation of cell growth Source: UniProtKB

Cellular Location

Golgi apparatus membrane. According to PubMed:10426319, it also exists as a soluble form which has the same biological activities. The existence of such soluble form is however uncertain.

Topology

Extracellular: 1-6
Helical: 7-27
Cytoplasmic: 28-213

Wirges, A., Bunse, M., Joedicke, J. J., Blanc, E., Gudipati, V., Moles, M. W., ... & Rehm, A. (2022). EBAG9 silencing exerts an immune checkpoint function without aggravating adverse effects. Molecular Therapy.

Rehm, A., Wirges, A., Hoser, D., Fischer, C., Herda, S., Gerlach, K., ... & Höpken, U. E. (2022). EBAG9 controls CD8+ T cell memory formation responding to tumor challenge in mice. JCI insight, 7(11).

Laaber, K., Dubash, T. D., Melzer, A. M., Christiansen, T., Ha, N., Brors, B., ... & Ball, C. R. (2021). A gene activating in vivo screen identifies EBAG9 as novel metastasis regulator in human colorectal cancer. Cancer Research, 81(13_Supplement), 2852-2852.

Muungo, L. (2020). EBAG9 is a tumor‐promoting and prognostic factor for bladder cancer.

Miyazaki, T., Ikeda, K., Sato, W., Horie-Inoue, K., & Inoue, S. (2018). Extracellular vesicle-mediated EBAG9 transfer from cancer cells to tumor microenvironment promotes immune escape and tumor progression. Oncogenesis, 7(1), 1-11.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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