Rat Anti-ECE2 Recombinant Antibody (CBFYE-0403) (V2LY-0425-LY1333)

Name: Rat Anti-ECE2 Recombinant Antibody (CBFYE-0403)
SKU: V2LY-0425-LY1333
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Rat

Specificity

Human

Clone

CBFYE-0403

Antibody Isotype

IgG2a

Application

IHC-P, WB, ELISA

Basic Information

Immunogen

Recombinant human ECE-2 (Val104-Leu787).

Host Species

Rat

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1 µg/ml
IHC-P	8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

Trehalose & PBS

Preservative

None

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Endothelin Converting Enzyme 2

Entrez Gene ID

9718

UniProt ID

O60344

Research Area

Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May play a role in amyloid-beta processing (By similarity).

Biological Process

Cell-cell signaling Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Methylation Source: UniProtKB-KW
Peptide hormone processing Source: UniProtKB
Protein processing Source: GO_Central

Cellular Location

Golgi apparatus membrane; Secretory vesicle membrane

Topology

Cytoplasmic: 1-106
Helical: 107-127
Lumenal: 128-811

More Infomation

References

Turner, A. J., & Nalivaeva, N. N. (2022). Angiotensin-converting enzyme 2 (ACE2): Two decades of revelations and re-evaluation. Peptides, 170766.

Buchsbaum, I. Y., Kielkowski, P., Giorgio, G., O'Neill, A. C., Di Giaimo, R., Kyrousi, C., ... & Cappello, S. (2020). ECE 2 regulates neurogenesis and neuronal migration during human cortical development. EMBO reports, 21(5), e48204.

Liao, X., Cai, F., Sun, Z., Zhang, Y., Wang, J., Jiao, B., ... & Song, W. (2020). Identification of Alzheimer’s disease–associated rare coding variants in the ECE2 gene. JCI insight, 5(4).

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

Rat Anti-ECE2 Recombinant Antibody (CBFYE-0403)

Related Products

Rat Anti-ECE2 Recombinant Antibody (CBFYE-0403)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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