Rat Anti-ECE2 Recombinant Antibody (CBFYE-0403) (CBMAB-E0715-FY)

This product is rat antibody that recognizes ECE2. The antibody CBFYE-0403 can be used for immunoassay techniques such as: IHC-P, WB.
See all ECE2 antibodies

Datasheet

Summary

Host Animal

Rat

Specificity

Human

Clone

CBFYE-0403

Antibody Isotype

IgG2a

Application

IHC-P, WB

Basic Information

Immunogen

Mouse myeloma cell line NS0-derived recombinant human ECE-2 Val104-Leu787

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 5% trehalose

Concentration

0.5 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

Endothelin Converting Enzyme 2

Introduction

ECE2 (Endothelin Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ECE2 include Alzheimer Disease. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and metalloendopeptidase activity. An important paralog of this gene is ECE1.

Entrez Gene ID

9718

UniProt ID

O60344

Alternative Names

Endothelin Converting Enzyme 2; EC 3.4.24.71; EC 3.4.24; KIAA0604; ECE-2

Research Area

Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May play a role in amyloid-beta processing (By similarity).

Biological Process

Cell-cell signaling Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Methylation Source: UniProtKB-KW
Peptide hormone processing Source: UniProtKB
Protein processing Source: GO_Central

Cellular Location

Golgi apparatus membrane; Secretory vesicle membrane

Topology

Cytoplasmic: 1-106
Helical: 107-127
Lumenal: 128-811

References

Turner, A. J., & Nalivaeva, N. N. (2022). Angiotensin-converting enzyme 2 (ACE2): Two decades of revelations and re-evaluation. Peptides, 170766.

Buchsbaum, I. Y., Kielkowski, P., Giorgio, G., O'Neill, A. C., Di Giaimo, R., Kyrousi, C., ... & Cappello, S. (2020). ECE 2 regulates neurogenesis and neuronal migration during human cortical development. EMBO reports, 21(5), e48204.

Liao, X., Cai, F., Sun, Z., Zhang, Y., Wang, J., Jiao, B., ... & Song, W. (2020). Identification of Alzheimer’s disease–associated rare coding variants in the ECE2 gene. JCI insight, 5(4).

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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