Human Recombinant ECE2 protein, His Tag (V2LY-0526-LY3679)

Name: Human Recombinant ECE2 protein, His Tag
SKU: V2LY-0526-LY3679
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant ECE2 protein, His Tag consist of Amino Acid: 199-883 and predicts a molecular mass of 80.2 kDa.

Molecule Mass

80.2 kDa

Sequence

Amino Acid: 199-883

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>93% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Endothelin Converting Enzyme 2

Research Area

Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May play a role in amyloid-beta processing (By similarity).

Biological Process

Cell-cell signaling Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Methylation Source: UniProtKB-KW
Peptide hormone processing Source: UniProtKB
Protein processing Source: GO_Central

Cellular Location

Golgi apparatus membrane; Secretory vesicle membrane

Topology

Cytoplasmic: 1-106
Helical: 107-127
Lumenal: 128-811

Turner, A. J., & Nalivaeva, N. N. (2022). Angiotensin-converting enzyme 2 (ACE2): Two decades of revelations and re-evaluation. Peptides, 170766.

Buchsbaum, I. Y., Kielkowski, P., Giorgio, G., O'Neill, A. C., Di Giaimo, R., Kyrousi, C., ... & Cappello, S. (2020). ECE 2 regulates neurogenesis and neuronal migration during human cortical development. EMBO reports, 21(5), e48204.

Liao, X., Cai, F., Sun, Z., Zhang, Y., Wang, J., Jiao, B., ... & Song, W. (2020). Identification of Alzheimer’s disease–associated rare coding variants in the ECE2 gene. JCI insight, 5(4).

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant ECE2 protein, hFc Tag (CAT#: V2LY-0526-LY3678)

Human ECE2 ELISA Kit (CAT#: V2LY-0626-LY4544)

Related Products

Rat Anti-ECE2 Recombinant Antibody (CBFYE-0403) (CAT#: CBMAB-E0715-FY)

Human ECE2 ELISA Kit (CAT#: V2LY-0626-LY4544)

Rat Anti-ECE2 Recombinant Antibody (CBFYE-0403) (CAT#: V2LY-0425-LY1333)

Human Recombinant ECE2 protein, hFc Tag (CAT#: V2LY-0526-LY3678)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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