ECE2

ECE2 (Endothelin Converting Enzyme 2) is a Protein Coding gene. Diseases associated with ECE2 include Alzheimer Disease. Among its related pathways are Peptide ligand-binding receptors and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include methyltransferase activity and metalloendopeptidase activity. An important paralog of this gene is ECE1.
Full Name
Endothelin Converting Enzyme 2
Research Area
Converts big endothelin-1 to endothelin-1. Also involved in the processing of various neuroendocrine peptides, including neurotensin, angiotensin I, substance P, proenkephalin-derived peptides, and prodynorphin-derived peptides. May play a role in amyloid-beta processing (By similarity).
Biological Process
Cell-cell signaling Source: UniProtKB
G protein-coupled receptor signaling pathway Source: Reactome
Methylation Source: UniProtKB-KW
Peptide hormone processing Source: UniProtKB
Protein processing Source: GO_Central
Cellular Location
Golgi apparatus membrane; Secretory vesicle membrane
Topology
Cytoplasmic: 1-106
Helical: 107-127
Lumenal: 128-811
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Anti-ECE2 antibodies

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Human ECE2 ELISA Kit (V2LY-0626-LY4544)

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Target: ECE2
Sensitivity: 0.0097 ng/mL
Detection Range: 0.02-6 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Human Recombinant ECE2 protein, His Tag (V2LY-0526-LY3679)

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Target: ECE2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 199-883
Tag: His Tag
Datasheet SDS

Human Recombinant ECE2 protein, hFc Tag (V2LY-0526-LY3678)

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Target: ECE2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 199-883
Tag: hFc Tag
Datasheet SDS

Rat Anti-ECE2 Recombinant Antibody (CBFYE-0403) (V2LY-0425-LY1333)

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Target: ECE2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-0403
Application*: P, WB, E
Datasheet SDS

Rat Anti-ECE2 Recombinant Antibody (CBFYE-0403) (CBMAB-E0715-FY)

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Target: ECE2
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYE-0403
Application*: P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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