Mouse Anti-EID1 Recombinant Antibody (EG1057) (V2LY-0425-LY1622)

Name: Mouse Anti-EID1 Recombinant Antibody (EG1057)
SKU: V2LY-0425-LY1622
Rating: 5 (1 reviews)

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Datasheet

Summary

Host Animal

Mouse

Specificity

Human

Clone

EG1057

Antibody Isotype

IgG2a

Application

ELISA, IF, WB

Basic Information

Immunogen

Synthetic peptide containing amino acids 159-187 of human DIE1 protein.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1 μg/ml
IF(ICC)	1-5 μg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Glycerol & PBS

Preservative

None

Concentration

1 mg/ml

Purity

>95% as determined by analysis by SDS-PAGE

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

EP300 Interacting Inhibitor Of Differentiation 1

Entrez Gene ID

23741

UniProt ID

Q9Y6B2

Research Area

Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.

Biological Process

Cell cycle Source: UniProtKB-KW
Cell differentiation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: MGI
Regulation of cell differentiation Source: InterPro

Cellular Location

Cytoplasm; Nucleus. May shuttle between nucleus and cytoplasm.

PTM

Ubiquitinated in U2OS osteosarcoma cells and is rapidly degraded by proteasome as cells exit the cell cycle exit.

More Infomation

References

Li, Y., Feng, J., Bian, Y., Cheng, W., & Qiao, C. (2022). EID1 plays a protective role in early-onset pre-eclampsia via promoting proliferation and invasion in trophoblast cells. Folia Histochemica et Cytobiologica, 60(1), 31-43.

Fu, X., Ding, B., Wang, C., Chen, C., Wang, J., Fei, X., & Xu, R. (2019). EID1 plays a crucial role in proliferation of neural stem cell. Biochemical and biophysical research communications, 512(4), 763-769.

Fu, X., Luo, L., Yi, R., Ding, B., Wang, C., Zhang, W., ... & Xu, R. (2019). Transcriptome profiling in Eid1-KO mice brain shows that Eid1 links cell proliferation in the brain. Gene, 717, 143998.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Associated Products

Alternative Versions

Rabbit Anti-EID1 Recombinant Antibody (EG1057)

Related Products

Rabbit Anti-EID1 Recombinant Antibody (EG1057)

Mouse Anti-EID1 Recombinant Antibody (CBFYE-0630)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
Request for COA

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Second antibody and isotype control

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