Mouse Anti-EID1 Recombinant Antibody (CBFYE-0630) (CBMAB-E1036-FY)

This product is mouse antibody that recognizes EID1. The antibody CBFYE-0630 can be used for immunoassay techniques such as: WB, ELISA, IF.
See all EID1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Mouse, Rat, Human

Clone

CBFYE-0630

Antibody Isotype

IgG2a

Application

WB, ELISA, IF

Basic Information

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Concentration

1 mg/mL

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name

EP300 Interacting Inhibitor Of Differentiation 1

Introduction

EID1 (EP300 Interacting Inhibitor Of Differentiation 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transcription corepressor activity and histone acetyltransferase regulator activity.

Entrez Gene ID

Human	23741
Mouse	58521
Rat	499882

UniProt ID

Human	Q9Y6B2
Mouse	Q9DCR4
Rat	B1WC74

Alternative Names

EP300 Interacting Inhibitor Of Differentiation 1; CREBBP/EP300 Inhibitory Protein 1; E1A-Like Inhibitor Of Differentiation 1; 21 KDa PRb-Associated Protein; CREBBP/EP300 Inhibitor 1; C15orf3; EID-1; RBP21; CRI1

Research Area

Interacts with RB1 and EP300 and acts as a repressor of MYOD1 transactivation. Inhibits EP300 and CBP histone acetyltransferase activity. May be involved in coupling cell cycle exit to the transcriptional activation of genes required for cellular differentiation. May act as a candidate coinhibitory factor for NR0B2 that can be directly linked to transcription inhibitory mechanisms.

Biological Process

Cell cycle Source: UniProtKB-KW
Cell differentiation Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: MGI
Regulation of cell differentiation Source: InterPro

Cellular Location

Cytoplasm; Nucleus. May shuttle between nucleus and cytoplasm.

PTM

Ubiquitinated in U2OS osteosarcoma cells and is rapidly degraded by proteasome as cells exit the cell cycle exit.

References

Li, Y., Feng, J., Bian, Y., Cheng, W., & Qiao, C. (2022). EID1 plays a protective role in early-onset pre-eclampsia via promoting proliferation and invasion in trophoblast cells. Folia Histochemica et Cytobiologica, 60(1), 31-43.

Fu, X., Ding, B., Wang, C., Chen, C., Wang, J., Fei, X., & Xu, R. (2019). EID1 plays a crucial role in proliferation of neural stem cell. Biochemical and biophysical research communications, 512(4), 763-769.

Fu, X., Luo, L., Yi, R., Ding, B., Wang, C., Zhang, W., ... & Xu, R. (2019). Transcriptome profiling in Eid1-KO mice brain shows that Eid1 links cell proliferation in the brain. Gene, 717, 143998.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Rabbit Anti-EID1 Recombinant Antibody (EG1057)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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