Mouse Anti-GAK Recombinant Antibody (CBFYH-3422) (CBMAB-H3968-FY)

Name: Mouse Anti-GAK Recombinant Antibody (CBFYH-3422)
SKU: CBMAB-H3968-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYH-3422

Application

Immunogen

Recombinant rat GAK

Specificity

Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

cyclin G associated kinase

Introduction

In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms.

Entrez Gene ID

81659

UniProt ID

P97874

Alternative Names

Cyclin G Associated Kinase; EC 2.7.11.1; Auxilin-2; Cyclin-G-Associated Kinase; DNAJC26; DNAJ26

Function

Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.

Biological Process

Cell cycle Source: UniProtKB-KW
Chaperone cofactor-dependent protein refolding Source: BHF-UCL
Clathrin coat disassembly Source: ParkinsonsUK-UCL
Clathrin-coated pit assembly Source: ParkinsonsUK-UCL
Clathrin-dependent endocytosis Source: ParkinsonsUK-UCL
Endoplasmic reticulum organization Source: ParkinsonsUK-UCL
Golgi organization Source: ParkinsonsUK-UCL
Golgi to lysosome transport Source: ParkinsonsUK-UCL
Negative regulation of neuron projection development Source: ParkinsonsUK-UCL
Protein localization to Golgi apparatus Source: ParkinsonsUK-UCL
Protein localization to plasma membrane Source: ParkinsonsUK-UCL
Receptor-mediated endocytosis Source: ParkinsonsUK-UCL
Synaptic vesicle uncoating Source: BHF-UCL

Cellular Location

Trans-Golgi network; Perinuclear region; Focal adhesion. Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Antibody Pairs

GAK Matched Antibody Pair (461) (CAT#: APMAB-461LY)

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Mouse Anti-GAK Recombinant Antibody (1C2) (CAT#: CBMAB-G1830-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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