GAK

In all eukaryotes, the cell cycle is governed by cyclin-dependent protein kinases (CDKs), whose activities are regulated by cyclins and CDK inhibitors in a diverse array of mechanisms that involve the control of phosphorylation and dephosphorylation of Ser, Thr or Tyr residues. Cyclins are molecules that possess a consensus domain called the 'cyclin box.' In mammalian cells, 9 cyclin species have been identified, and they are referred to as cyclins A through I. Cyclin G is a direct transcriptional target of the p53 tumor suppressor gene product and thus functions downstream of p53. GAK is an association partner of cyclin G and CDK5. Alternative splicing results in multiple transcript variants encoding different isoforms.
Full Name
cyclin G associated kinase
Function
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
Biological Process
Cell cycle Source: UniProtKB-KW
Chaperone cofactor-dependent protein refolding Source: BHF-UCL
Clathrin coat disassembly Source: ParkinsonsUK-UCL
Clathrin-coated pit assembly Source: ParkinsonsUK-UCL
Clathrin-dependent endocytosis Source: ParkinsonsUK-UCL
Endoplasmic reticulum organization Source: ParkinsonsUK-UCL
Golgi organization Source: ParkinsonsUK-UCL
Golgi to lysosome transport Source: ParkinsonsUK-UCL
Negative regulation of neuron projection development Source: ParkinsonsUK-UCL
Protein localization to Golgi apparatus Source: ParkinsonsUK-UCL
Protein localization to plasma membrane Source: ParkinsonsUK-UCL
Receptor-mediated endocytosis Source: ParkinsonsUK-UCL
Synaptic vesicle uncoating Source: BHF-UCL
Cellular Location
Trans-Golgi network; Perinuclear region; Focal adhesion. Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.
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Anti-GAK antibodies

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Mouse Anti-GAK Recombinant Antibody (CBFYH-3422) (CBMAB-H3968-FY)

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Target: GAK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: CBFYH-3422
Application*: WB
Datasheet SDS

Mouse Anti-GAK Recombinant Antibody (1C2) (CBMAB-G1830-LY)

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Target: GAK
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat, Human, Mouse
Clone: 1C2
Application*: WB
Datasheet SDS

Mouse Anti-GAK Recombinant Antibody (4C10) (CBMAB-G1831-LY)

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Target: GAK
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4C10
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-GAK Recombinant Antibody (6) (CBMAB-G0149-LY)

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Target: GAK
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: 6
Application*: WB, IP, IF, E, P
Datasheet SDS

Alpaca Anti-GAK Recombinant VHH (CBFYH-3422) (V2LY-1225-LY606)

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Target: GAK
Host: Alpaca
Antibody Isotype: VHH
Specificity: Human
Clone: CBFYH-3422
Application*: E
Datasheet SDS

Rabbit Anti-GAK Recombinant Antibody (EG1279) (V2LY-1225-LY607)

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Target: GAK
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: EG1279
Application*: WB, IP
Datasheet SDS

Mouse Anti-GAK Recombinant Antibody (1C2) (V2LY-1225-LY605)

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Target: GAK
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1C2
Application*: WB, E, IP
Datasheet SDS

Mouse Anti-GAK Recombinant Antibody (4C10) (V2LY-1225-LY604)

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Target: GAK
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse, Rat
Clone: 4C10
Application*: WB, IP, IF, E, P
Datasheet SDS

Rabbit Anti-GAK Recombinant Antibody (EG1279) (CBMAB-EN1543-LY)

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Target: GAK
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: EG1279
Application*: WB: 1:500~1:1000 ELISA: 1:5000
Datasheet SDS

GAK Matched Antibody Pair (461) (APMAB-461LY)

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Target: GAK
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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