Human Recombinant GAK, Active protein, GST Tag (V2LY-0526-LY4239)

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Basic Information

Expressed Host
Baculovirus-Insect Cells
Protein Species
Human
Tag
GST Tag
Protein Construction
This product is Human Recombinant GAK, Active protein, GST Tag consist of Amino Acid: 1-396 and predicts a molecular mass of 68 kDa.
Molecule Mass
68 kDa
Sequence
Amino Acid: 1-396
Species
Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity
Batch dependent.
Endotoxin
Please contact us for more information.
Format
Liquid
Preservative
None
Storage
Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
More Infomation

Target

Full Name
cyclin G associated kinase
Function
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1.
Biological Process
Cell cycle Source: UniProtKB-KW
Chaperone cofactor-dependent protein refolding Source: BHF-UCL
Clathrin coat disassembly Source: ParkinsonsUK-UCL
Clathrin-coated pit assembly Source: ParkinsonsUK-UCL
Clathrin-dependent endocytosis Source: ParkinsonsUK-UCL
Endoplasmic reticulum organization Source: ParkinsonsUK-UCL
Golgi organization Source: ParkinsonsUK-UCL
Golgi to lysosome transport Source: ParkinsonsUK-UCL
Negative regulation of neuron projection development Source: ParkinsonsUK-UCL
Protein localization to Golgi apparatus Source: ParkinsonsUK-UCL
Protein localization to plasma membrane Source: ParkinsonsUK-UCL
Receptor-mediated endocytosis Source: ParkinsonsUK-UCL
Synaptic vesicle uncoating Source: BHF-UCL
Cellular Location
Trans-Golgi network; Perinuclear region; Focal adhesion. Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions.
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For research use only. Not intended for any clinical use.

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