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Mouse Anti-IFI30 Recombinant Antibody (844623) (CBMAB-G1078-LY)

This product is antibody recognizes IFI30. The antibody 844623 immunoassay techniques such as: WB.
See all IFI30 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
844623
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
HEK293 human embryonic kidney cell line transfected with human GILT/IFI30, Ser27-Lys250, Accession # P13284
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
lyophilized
Buffer
Trehalose
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ifi30, Lysosomal Thiol Reductase
Introduction
The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq, Jul 2008]
Entrez Gene ID
10437
UniProt ID
P13284
Alternative Names
IFI30; Lysosomal Thiol Reductase
Function
Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity).

Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity).
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class I Source: UniProtKB
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Negative regulation of fibroblast proliferation Source: Ensembl
Protein stabilization Source: Ensembl
Cellular Location
Lysosome; Secreted
PTM
N-glycosylated. Sugar chains contain mannose-6-phosphate.
Synthesized as a 35 kDa precursor which is then processed into the mature 30 kDa form via cleavage of N-terminal and C-terminal propeptides. Processing of the precursor is mediated by multiple lysosomal proteases.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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