Mouse Anti-IFI30 Recombinant Antibody (MaP.IP30) (CBMAB-G6125-LY)

Name: Mouse Anti-IFI30 Recombinant Antibody (MaP.IP30)
SKU: CBMAB-G6125-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

MaP.IP30

Application

Immunogen

Partial purified IP30 (purified from human B-LCL)

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

0.1% BSA

Preservative

0.02% NaN3

Concentration

0.1 mg/mL

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Ifi30, Lysosomal Thiol Reductase

Introduction

The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing. [provided by RefSeq, Jul 2008]

Entrez Gene ID

10437

UniProt ID

P13284

Alternative Names

IFI30; Lysosomal Thiol Reductase

Function

Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity).

Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity).

Biological Process

Antigen processing and presentation of exogenous peptide antigen via MHC class I Source: UniProtKB
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Negative regulation of fibroblast proliferation Source: Ensembl
Protein stabilization Source: Ensembl

Cellular Location

Lysosome; Secreted

PTM

N-glycosylated. Sugar chains contain mannose-6-phosphate.
Synthesized as a 35 kDa precursor which is then processed into the mature 30 kDa form via cleavage of N-terminal and C-terminal propeptides. Processing of the precursor is mediated by multiple lysosomal proteases.

Chen, Y., Xu, H., Yu, P., Wang, Q., Li, S., Ji, F., ... & Lan, Q. (2023). Interferon‐γ inducible protein 30 promotes the epithelial–mesenchymal transition‐like phenotype and chemoresistance by activating EGFR/AKT/GSK3β/β‐catenin pathway in glioma. CNS Neuroscience & Therapeutics.

Wang, X., Ge, X., Qin, Y., Liu, D., & Chen, C. (2022). Ifi30 Is Required for Sprouting Angiogenesis During Caudal Vein Plexus Formation in Zebrafish. Frontiers in Physiology, 13, 919579.

Fan, Y., Wang, X., & Li, Y. (2021). IFI30 expression predicts patient prognosis in breast cancer and dictates breast cancer cells proliferation via regulating autophagy. International Journal of Medical Sciences, 18(14), 3342.

Jiang, W., Zheng, F., Yao, T., Gong, F., Zheng, W., & Yao, N. (2021). IFI30 as a prognostic biomarker and correlation with immune infiltrates in glioma. Annals of Translational Medicine, 9(22).

Zhu, C., Chen, X., Guan, G., Zou, C., Guo, Q., Cheng, P., ... & Wu, A. (2020). IFI30 is a novel immune-related target with predicting value of prognosis and treatment response in glioblastoma. OncoTargets and therapy, 1129-1143.

Guo, J., Zhou, M., Liu, X., Pan, Y., Yang, R., Zhao, Z., & Sun, B. (2018). Porcine IFI30 inhibits PRRSV proliferation and host cell apoptosis in vitro. Gene, 649, 93-98.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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