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IFI30

The protein encoded by this gene is a lysosomal thiol reductase that at low pH can reduce protein disulfide bonds. The enzyme is expressed constitutively in antigen-presenting cells and induced by gamma-interferon in other cell types. This enzyme has an important role in MHC class II-restricted antigen processing.
Full Name
Ifi30, Lysosomal Thiol Reductase
Function
Lysosomal thiol reductase that can reduce protein disulfide bonds. May facilitate the complete unfolding of proteins destined for lysosomal degradation. Plays an important role in antigen processing. Facilitates the generation of MHC class II-restricted epitodes from disulfide bond-containing antigen by the endocytic reduction of disulfide bonds (By similarity).

Facilitates also MHC class I-restricted recognition of exogenous antigens containing disulfide bonds by CD8+ T-cells or crosspresentation (By similarity).
Biological Process
Antigen processing and presentation of exogenous peptide antigen via MHC class I Source: UniProtKB
Antigen processing and presentation of exogenous peptide antigen via MHC class II Source: Reactome
Negative regulation of fibroblast proliferation Source: Ensembl
Protein stabilization Source: Ensembl
Cellular Location
Lysosome; Secreted
PTM
N-glycosylated. Sugar chains contain mannose-6-phosphate.
Synthesized as a 35 kDa precursor which is then processed into the mature 30 kDa form via cleavage of N-terminal and C-terminal propeptides. Processing of the precursor is mediated by multiple lysosomal proteases.
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Anti-IFI30 antibodies

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Mouse Anti-IFI30 Recombinant Antibody (MaP.IP30) (CBMAB-G6125-LY)

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Target: IFI30
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: MaP.IP30
Application*: F
Datasheet SDS

Mouse Anti-IFI30 Recombinant Antibody (844623) (CBMAB-G1078-LY)

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Target: IFI30
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 844623
Application*: WB
Datasheet SDS

Recombinant Mouse Anti-IFI30 Antibody (CBHb304) (CBMAB-Hb515-LY)

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Target: IFI30
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBHb304
Application*: FC, IF, IP
Datasheet SDS

Recombinant Mouse Anti-IFI30 Antibody (CBHb099) (CBMAB-Hb514-LY)

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Target: IFI30
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBHb099
Application*: FC, IF, IP, WB
Datasheet SDS

Mouse Anti-IFI30 Recombinant Antibody (CBFYA-0066) (CBMAB-X0097-FY)

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Target: IFI30
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYA-0066
Application*: F, IF, IP, WB
Datasheet SDS

Mouse Anti-IFI30 Recombinant Antibody (CBYY-I1310) (CBMAB-I2480-YY)

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Target: IFI30
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I1310
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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