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Mouse Anti-KARS Recombinant Antibody (13B435) (CBMAB-K0397-LY)

This product is antibody recognizes KARS. The antibody 13B435 immunoassay techniques such as: ELISA, IHC, WB.
See all KARS antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
13B435
Antibody Isotype
IgG
Application
ELISA, IHC, WB

Basic Information

Immunogen
Purified recombinant fragment of KARS(aa90-174) expressed in E. coli
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.03% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Lysyl-TRNA Synthetase
Introduction
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. It has been shown to be a target of autoantibodies in the human autoimmune diseases, polymyositis or dermatomyositis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
3735
UniProt ID
Q15046
Alternative Names
Lysyl-TRNA Synthetase; Lysine TRNA Ligase; EC 6.1.1.6; LysRS; Deafness; Autosomal Recessive 89; Lysine--TRNA Ligase; EC 2.7.7.-; KIAA0070;
Function
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:9278442, PubMed:18029264, PubMed:18272479).
When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690).
Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:5338216, PubMed:14975237, PubMed:19524539, PubMed:23159739).
(Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation.
Biological Process
Basophil activation involved in immune responseManual Assertion Based On ExperimentIGI:CAFA
Diadenosine tetraphosphate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIGI:CAFA
Lysyl-tRNA aminoacylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of inflammatory response to antigenic stimulusManual Assertion Based On ExperimentIDA:CAFA
Positive regulation of macrophage activationManual Assertion Based On ExperimentIDA:CAFA
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIGI:CAFA
Response to X-rayIEA:Ensembl
tRNA processing1 PublicationNAS:UniProtKB
PTM
Phosphorylated on a serine residue after mast cell stimulation with immunoglobulin E (IgE).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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