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Rabbit Anti-KARS Recombinant Antibody (CBYJL-257) (CBMAB-L0361-YJ)

Provided herein is a Rabbit monoclonal antibody, which binds to Lysyl-TRNA Synthetase (KARS). The antibody can be used for immunoassay techniques, such as WB, IP, IF.
See all KARS antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
CBYJL-257
Antibody Isotype
IgG
Application
WB, IP, IF

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Lysyl-TRNA Synthetase
Introduction
Aminoacyl-tRNA synthetases are a class of enzymes that charge tRNAs with their cognate amino acids. Lysyl-tRNA synthetase is a homodimer localized to the cytoplasm which belongs to the class II family of tRNA synthetases. KARS has been shown to be a target of autoantibodies in the human autoimmune diseases, dermatomyositis or polymyositis. It has been found that alternatively spliced transcript variants encode different isoforms for this gene.
Entrez Gene ID
Human3735
Mouse85305
Rat292028
Monkey714516
UniProt ID
HumanQ15046
MouseQ99MN1
RatQ5XIM7
MonkeyA0A5F8AFE5
Alternative Names
Lysyl-TRNA Synthetase; Lysine TRNA Ligase; EC 6.1.1.6; LysRS; Deafness; Autosomal Recessive 89; Lysine--TRNA Ligase; EC 2.7.7.-; KIAA0070
Function
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:9278442, PubMed:18029264, PubMed:18272479).
When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690).
Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:5338216, PubMed:14975237, PubMed:19524539, PubMed:23159739).
(Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation.
Biological Process
Basophil activation involved in immune responseManual Assertion Based On ExperimentIGI:CAFA
Diadenosine tetraphosphate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIGI:CAFA
Lysyl-tRNA aminoacylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of inflammatory response to antigenic stimulusManual Assertion Based On ExperimentIDA:CAFA
Positive regulation of macrophage activationManual Assertion Based On ExperimentIDA:CAFA
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIGI:CAFA
Response to X-rayIEA:Ensembl
tRNA processing1 PublicationNAS:UniProtKB
PTM
Phosphorylated on a serine residue after mast cell stimulation with immunoglobulin E (IgE).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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