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Mouse Anti-KARS Recombinant Antibody (CBT858) (V2LY-0625-LY3222)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT858
Antibody Isotype
IgG
Application
WB, IHC-P, IF, ELISA

Basic Information

Immunogen
Purified recombinant fragment of LysRS(aa90-174) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
ELISA1:10,000
IHC1:200-1:1,000
WB1:500-1:2,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Buffer
BSA, Glycerol
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Lysyl-TRNA Synthetase
Entrez Gene ID
3735
UniProt ID
Q15046
Function
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA (PubMed:9278442, PubMed:18029264, PubMed:18272479).
When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages (PubMed:15851690).
Catalyzes the synthesis of the signaling molecule diadenosine tetraphosphate (Ap4A), and thereby mediates disruption of the complex between HINT1 and MITF and the concomitant activation of MITF transcriptional activity (PubMed:5338216, PubMed:14975237, PubMed:19524539, PubMed:23159739).
(Microbial infection) Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), the primer for reverse transcription initiation.
Biological Process
Basophil activation involved in immune responseManual Assertion Based On ExperimentIGI:CAFA
Diadenosine tetraphosphate biosynthetic processManual Assertion Based On ExperimentIDA:UniProtKB
ERK1 and ERK2 cascadeManual Assertion Based On ExperimentIGI:CAFA
Lysyl-tRNA aminoacylationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of inflammatory response to antigenic stimulusManual Assertion Based On ExperimentIDA:CAFA
Positive regulation of macrophage activationManual Assertion Based On ExperimentIDA:CAFA
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIGI:CAFA
Response to X-rayIEA:Ensembl
tRNA processing1 PublicationNAS:UniProtKB
PTM
Phosphorylated on a serine residue after mast cell stimulation with immunoglobulin E (IgE).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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