Mouse Anti-MICB Recombinant Antibody (CBFYM-0243) (CBMAB-M0304-FY)

Name: Mouse Anti-MICB Recombinant Antibody (CBFYM-0243)
SKU: CBMAB-M0304-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBFYM-0243

Application

Immunogen

Recombinant human MICB

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

MHC CLASS I POLYPEPTIDE-RELATED SEQUENCE B

Introduction

This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. Alternative splicing results in multiple transcript variants.

Entrez Gene ID

4277

UniProt ID

Q29980

Alternative Names

MHC Class I Polypeptide-Related Sequence B; PERB11.2; MHC Class I-Like Molecule PERB11.2-IMX; MHC Class I Chain-Related Protein B; Stress Inducible Class I Homolog; MHC Class I Mic-B Antigen; MIC-B

Function

Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.

Biological Process

Adaptive immune response Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Gamma-delta T cell activation Source: UniProtKB
Immune response-activating cell surface receptor signaling pathway Source: UniProtKB
Negative regulation of defense response to virus by host Source: UniProtKB
Response to heat Source: UniProtKB
Response to oxidative stress Source: UniProtKB
Response to retinoic acid Source: UniProtKB

Cellular Location

Plasma membrane
Cell membrane
Note: Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.

Involvement in disease

Rheumatoid arthritis (RA):
An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.

Topology

Extracellular: 23-309
Helical: 310-330
Cytoplasmic: 331-383

PTM

Proteolytically cleaved and released from the cell surface of tumor cells.

Wei, A., Zhang, L., Ma, H., Cui, L., Zhang, Q., Wang, D., ... & Li, Z. (2023). Clinical Significance of Plasma Soluble MICB in Children With EBV-associated Hemophagocytic Lymphohistiocytosis. Journal of Pediatric Hematology/Oncology, 45(4), e446-e454.

Shadrina, A. S., Elgaeva, E. E., Stanaway, I. B., Jarvik, G. P., Namjou, B., Wei, W. Q., ... & Tsepilov, Y. A. (2022). Mendelian randomization analysis of plasma levels of CD209 and MICB proteins and the risk of varicose veins of lower extremities. Plos one, 17(5), e0268725.

Closa, L., Vidal, F., Herrero, M. J., & Caro, J. L. (2021). High‐throughput genotyping of HLA‐G, HLA‐F, MICA, and MICB and analysis of frequency distributions in healthy blood donors from Catalonia. HLA, 97(5), 420-427.

Mansourabadi, Z., Razmkhah, M., Mohtasebi, M. S., Talei, A. R., & Ghaderi, A. (2019). Expression of major histocompatibility complex class I polypeptide-related sequence B in adipose-derived stem cells from breast cancer patients and normal individuals. Journal of Cancer Research and Therapeutics, 15(5), 1067-1072.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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