Human Recombinant MICB protein, hFc Tag (V2LY-0526-LY5581)

Name: Human Recombinant MICB protein, hFc Tag
SKU: V2LY-0526-LY5581
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

hFc Tag

Protein Construction

This product is Human Recombinant MICB protein, hFc Tag consist of Amino Acid: 1-298 and predicts a molecular mass of 59.5 kDa.

Molecule Mass

59.5 kDa

Sequence

Amino Acid: 1-298

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥90% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

MHC CLASS I POLYPEPTIDE-RELATED SEQUENCE B

Function

Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.

Biological Process

Adaptive immune response Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Gamma-delta T cell activation Source: UniProtKB
Immune response-activating cell surface receptor signaling pathway Source: UniProtKB
Negative regulation of defense response to virus by host Source: UniProtKB
Response to heat Source: UniProtKB
Response to oxidative stress Source: UniProtKB
Response to retinoic acid Source: UniProtKB

Cellular Location

Plasma membrane
Cell membrane
Note: Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.

Involvement in disease

Rheumatoid arthritis (RA):
An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.

Topology

Extracellular: 23-309
Helical: 310-330
Cytoplasmic: 331-383

PTM

Proteolytically cleaved and released from the cell surface of tumor cells.

Wei, A., Zhang, L., Ma, H., Cui, L., Zhang, Q., Wang, D., ... & Li, Z. (2023). Clinical Significance of Plasma Soluble MICB in Children With EBV-associated Hemophagocytic Lymphohistiocytosis. Journal of Pediatric Hematology/Oncology, 45(4), e446-e454.

Shadrina, A. S., Elgaeva, E. E., Stanaway, I. B., Jarvik, G. P., Namjou, B., Wei, W. Q., ... & Tsepilov, Y. A. (2022). Mendelian randomization analysis of plasma levels of CD209 and MICB proteins and the risk of varicose veins of lower extremities. Plos one, 17(5), e0268725.

Closa, L., Vidal, F., Herrero, M. J., & Caro, J. L. (2021). High‐throughput genotyping of HLA‐G, HLA‐F, MICA, and MICB and analysis of frequency distributions in healthy blood donors from Catalonia. HLA, 97(5), 420-427.

Mansourabadi, Z., Razmkhah, M., Mohtasebi, M. S., Talei, A. R., & Ghaderi, A. (2019). Expression of major histocompatibility complex class I polypeptide-related sequence B in adipose-derived stem cells from breast cancer patients and normal individuals. Journal of Cancer Research and Therapeutics, 15(5), 1067-1072.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant MICB protein, His Tag (CAT#: V2LY-0526-LY5582)

Human Recombinant MICB protein, His Tag-1 (CAT#: V2LY-0526-LY5583)

Human MICB ELISA Kit (CAT#: V2LY-0626-LY4887)

Related Products

Mouse Anti-MICB (AA 23-298) Recombinant Antibody (CBFYM-0095) (CAT#: CBMAB-M0106-FY)

Mouse Anti-MICB Recombinant Antibody (CBT3035) (CAT#: V2LY-0625-LY1581)

Human MICB ELISA Kit (CAT#: V2LY-0626-LY4887)

Rabbit Anti-MICB Recombinant Antibody (CBFYM-2216) (CAT#: CBMAB-M2399-FY)

Mouse Anti-MICB Recombinant Antibody (CBFYM-0243) (CAT#: CBMAB-M0304-FY)

Human Recombinant MICB protein, His Tag (CAT#: V2LY-0526-LY5582)

Mouse Anti-MICB Recombinant Antibody (CBFYM-0002) (CAT#: CBMAB-M0002-FY)

Mouse Anti-MICB Recombinant Antibody (CBFYM-2215) (CAT#: CBMAB-M2398-FY)

Human Recombinant MICB protein, His Tag-1 (CAT#: V2LY-0526-LY5583)

Mouse Anti-MICB Recombinant Antibody (CBFYM-0367) (CAT#: CBMAB-M0448-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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