Human MICB ELISA Kit (V2LY-0626-LY4887)

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Tested Data
Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity
0.0095 ng/mL
Detection Range
0.02-4.5 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
42.6 kDa
Components
  • Pre-coated ELISA Plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
MHC CLASS I POLYPEPTIDE-RELATED SEQUENCE B
Function
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Gamma-delta T cell activation Source: UniProtKB
Immune response-activating cell surface receptor signaling pathway Source: UniProtKB
Negative regulation of defense response to virus by host Source: UniProtKB
Response to heat Source: UniProtKB
Response to oxidative stress Source: UniProtKB
Response to retinoic acid Source: UniProtKB
Cellular Location
Plasma membrane
Cell membrane
Note: Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.
Involvement in disease
Rheumatoid arthritis (RA):
An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Topology
Extracellular: 23-309
Helical: 310-330
Cytoplasmic: 331-383
PTM
Proteolytically cleaved and released from the cell surface of tumor cells.

Wei, A., Zhang, L., Ma, H., Cui, L., Zhang, Q., Wang, D., ... & Li, Z. (2023). Clinical Significance of Plasma Soluble MICB in Children With EBV-associated Hemophagocytic Lymphohistiocytosis. Journal of Pediatric Hematology/Oncology, 45(4), e446-e454.

Shadrina, A. S., Elgaeva, E. E., Stanaway, I. B., Jarvik, G. P., Namjou, B., Wei, W. Q., ... & Tsepilov, Y. A. (2022). Mendelian randomization analysis of plasma levels of CD209 and MICB proteins and the risk of varicose veins of lower extremities. Plos one, 17(5), e0268725.

Closa, L., Vidal, F., Herrero, M. J., & Caro, J. L. (2021). High‐throughput genotyping of HLA‐G, HLA‐F, MICA, and MICB and analysis of frequency distributions in healthy blood donors from Catalonia. HLA, 97(5), 420-427.

Mansourabadi, Z., Razmkhah, M., Mohtasebi, M. S., Talei, A. R., & Ghaderi, A. (2019). Expression of major histocompatibility complex class I polypeptide-related sequence B in adipose-derived stem cells from breast cancer patients and normal individuals. Journal of Cancer Research and Therapeutics, 15(5), 1067-1072.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant MICB protein, hFc Tag (CAT#: V2LY-0526-LY5581)

Human Recombinant MICB protein, His Tag (CAT#: V2LY-0526-LY5582)

Human Recombinant MICB protein, His Tag-1 (CAT#: V2LY-0526-LY5583)

Related Products

Mouse Anti-MICB Recombinant Antibody (CBT3035) (CAT#: V2LY-0625-LY1581)

Mouse Anti-MICB Recombinant Antibody (CBFYM-2215) (CAT#: CBMAB-M2398-FY)

Human Recombinant MICB protein, His Tag-1 (CAT#: V2LY-0526-LY5583)

Mouse Anti-MICB Recombinant Antibody (CBFYM-0002) (CAT#: CBMAB-M0002-FY)

Mouse Anti-MICB (AA 23-298) Recombinant Antibody (CBFYM-0095) (CAT#: CBMAB-M0106-FY)

Mouse Anti-MICB Recombinant Antibody (CBFYM-0243) (CAT#: CBMAB-M0304-FY)

Mouse Anti-MICB Recombinant Antibody (CBFYM-0367) (CAT#: CBMAB-M0448-FY)

Human Recombinant MICB protein, hFc Tag (CAT#: V2LY-0526-LY5581)

Rabbit Anti-MICB Recombinant Antibody (CBFYM-2216) (CAT#: CBMAB-M2399-FY)

Human Recombinant MICB protein, His Tag (CAT#: V2LY-0526-LY5582)

Isotype control

For research use only. Not intended for any clinical use.

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