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Mouse Anti-MICB Recombinant Antibody (CBT3035) (V2LY-0625-LY1581)


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Tested Data
Mouse Anti-MICB Recombinant Antibody (CBT3035) (V2LY-0625-LY1581) in ELISA
Mouse Anti-MICB Recombinant Antibody (CBT3035) (V2LY-0625-LY1581) in ELISA
Mouse Anti-MICB Recombinant Antibody (CBT3035) (V2LY-0625-LY1581) in WB
Mouse Anti-MICB Recombinant Antibody (CBT3035) (V2LY-0625-LY1581) in WB
Mouse Anti-MICB Recombinant Antibody (CBT3035) (V2LY-0625-LY1581) in FC
Mouse Anti-MICB Recombinant Antibody (CBT3035) (V2LY-0625-LY1581) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3035
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human MICB (AA: extra 23-309) expressed in HEK293-6e cells supernatant.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MHC CLASS I POLYPEPTIDE-RELATED SEQUENCE B
Entrez Gene ID
4277
UniProt ID
Q29980
Function
Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Cytolysis Source: UniProtKB-KW
Gamma-delta T cell activation Source: UniProtKB
Immune response-activating cell surface receptor signaling pathway Source: UniProtKB
Negative regulation of defense response to virus by host Source: UniProtKB
Response to heat Source: UniProtKB
Response to oxidative stress Source: UniProtKB
Response to retinoic acid Source: UniProtKB
Cellular Location
Plasma membrane
Cell membrane
Note: Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.
Involvement in disease
Rheumatoid arthritis (RA):
An inflammatory disease with autoimmune features and a complex genetic component. It primarily affects the joints and is characterized by inflammatory changes in the synovial membranes and articular structures, widespread fibrinoid degeneration of the collagen fibers in mesenchymal tissues, and by atrophy and rarefaction of bony structures.
Topology
Extracellular: 23-309
Helical: 310-330
Cytoplasmic: 331-383
PTM
Proteolytically cleaved and released from the cell surface of tumor cells.
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For research use only. Not intended for any clinical use.

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