Sign in or Register   Sign in or Register
  |  

Mouse Anti-MSI2 Recombinant Antibody (3B6) (CBMAB-A5619-LY)

The product is antibody recognizes MSI2. The antibody 3B6 immunoassay techniques such as: WB, ELISA.
See all MSI2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3B6
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
MSI2 (AAH01526, 1 a.a. ~ 328 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Musashi RNA Binding Protein 2
Introduction
This gene encodes a protein containing two conserved tandem RNA recognition motifs. Similar proteins in other species function as RNA-binding proteins and play central roles in posttranscriptional gene regulation. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq]
Entrez Gene ID
124540
UniProt ID
Q96DH6
Alternative Names
FLJ36569; MGC3245; MSI2H
Function
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
Biological Process
Stem cell development Source: Ensembl
Cellular Location
Cytoplasm
Note: Associated with polysomes.
Involvement in disease
Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).
PTM
Phosphorylated.

Sicking, M., Falke, I., Löblein, M. T., Eich, H. T., Götte, M., Greve, B., & Troschel, F. M. (2023). The Musashi RNA-binding proteins in female cancers: insights on molecular mechanisms and therapeutic relevance. Biomarker Research, 11(1), 76.

Suo, J., Zou, S., Wang, J., Han, Y., Zhang, L., Lv, C., ... & Zou, W. (2022). The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling. Bone Research, 10(1), 31.

Wang, J., Lan, L., Wu, X., Xu, L., & Miao, Y. (2022). Mechanism of RNA recognition by a Musashi RNA-binding protein. Current Research in Structural Biology, 4, 10-20.

Löblein, M. T., Falke, I., Eich, H. T., Greve, B., Götte, M., & Troschel, F. M. (2021). Dual knockdown of musashi RNA-binding proteins MSI-1 and MSI-2 attenuates putative cancer stem cell characteristics and therapy resistance in ovarian cancer cells. International Journal of Molecular Sciences, 22(21), 11502.

Sun, J., Sheng, W., Ma, Y., & Dong, M. (2021). Potential role of musashi-2 RNA-binding protein in cancer EMT. OncoTargets and therapy, 1969-1980.

Li, M., Li, A. Q., Zhou, S. L., Lv, H., Wei, P., & Yang, W. T. (2020). RNA-binding protein MSI2 isoforms expression and regulation in progression of triple-negative breast cancer. Journal of Experimental & Clinical Cancer Research, 39, 1-18.

Forouzanfar, M., Lachinani, L., Dormiani, K., Nasr-Esfahani, M. H., Gure, A. O., & Ghaedi, K. (2020). Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells. Stem Cell Research & Therapy, 11, 1-10.

Zhao, J., Zhang, Y., Liu, X. S., Zhu, F. M., Xie, F., Jiang, C. Y., ... & Han, B. M. (2020). RNA‐binding protein Musashi2 stabilizing androgen receptor drives prostate cancer progression. Cancer Science, 111(2), 369-382.

Troschel, F. M., Minte, A., Ismail, Y. M., Kamal, A., Abdullah, M. S., Ahmed, S. H., ... & Greve, B. (2020). Knockdown of musashi RNA binding proteins decreases radioresistance but enhances cell motility and invasion in triple-negative breast cancer. International Journal of Molecular Sciences, 21(6), 2169.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-MSI2 Recombinant Antibody (3B6)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare