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Mouse Anti-MSI2 Recombinant Antibody (CBT3122) (V2LY-0625-LY2552)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3122
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Purified recombinant fragment of human MSI2 expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Preservative
Sodium azide
Concentration
Batch dependent
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Musashi RNA Binding Protein 2
Entrez Gene ID
124540
UniProt ID
Q96DH6
Function
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
Biological Process
Stem cell development Source: Ensembl
Cellular Location
Cytoplasm
Note: Associated with polysomes.
Involvement in disease
Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).
PTM
Phosphorylated.
More Infomation

Sicking, M., Falke, I., Löblein, M. T., Eich, H. T., Götte, M., Greve, B., & Troschel, F. M. (2023). The Musashi RNA-binding proteins in female cancers: insights on molecular mechanisms and therapeutic relevance. Biomarker Research, 11(1), 76.

Suo, J., Zou, S., Wang, J., Han, Y., Zhang, L., Lv, C., ... & Zou, W. (2022). The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling. Bone Research, 10(1), 31.

Wang, J., Lan, L., Wu, X., Xu, L., & Miao, Y. (2022). Mechanism of RNA recognition by a Musashi RNA-binding protein. Current Research in Structural Biology, 4, 10-20.

Löblein, M. T., Falke, I., Eich, H. T., Greve, B., Götte, M., & Troschel, F. M. (2021). Dual knockdown of musashi RNA-binding proteins MSI-1 and MSI-2 attenuates putative cancer stem cell characteristics and therapy resistance in ovarian cancer cells. International Journal of Molecular Sciences, 22(21), 11502.

Sun, J., Sheng, W., Ma, Y., & Dong, M. (2021). Potential role of musashi-2 RNA-binding protein in cancer EMT. OncoTargets and therapy, 1969-1980.

Li, M., Li, A. Q., Zhou, S. L., Lv, H., Wei, P., & Yang, W. T. (2020). RNA-binding protein MSI2 isoforms expression and regulation in progression of triple-negative breast cancer. Journal of Experimental & Clinical Cancer Research, 39, 1-18.

Forouzanfar, M., Lachinani, L., Dormiani, K., Nasr-Esfahani, M. H., Gure, A. O., & Ghaedi, K. (2020). Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells. Stem Cell Research & Therapy, 11, 1-10.

Zhao, J., Zhang, Y., Liu, X. S., Zhu, F. M., Xie, F., Jiang, C. Y., ... & Han, B. M. (2020). RNA‐binding protein Musashi2 stabilizing androgen receptor drives prostate cancer progression. Cancer Science, 111(2), 369-382.

Troschel, F. M., Minte, A., Ismail, Y. M., Kamal, A., Abdullah, M. S., Ahmed, S. H., ... & Greve, B. (2020). Knockdown of musashi RNA binding proteins decreases radioresistance but enhances cell motility and invasion in triple-negative breast cancer. International Journal of Molecular Sciences, 21(6), 2169.

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For research use only. Not intended for any clinical use.

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