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Rabbit Anti-MSI2 Recombinant Antibody (CBFYM-2641) (CBMAB-M2830-FY)

This product is rabbit antibody that recognizes MSI2. The antibody CBFYM-2641 can be used for immunoassay techniques such as: WB, IHC-P, IF, FC.
See all MSI2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBFYM-2641
Antibody Isotype
IgG
Application
WB, IHC-P, IF, FC

Basic Information

Immunogen
Recombinant protein
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
TBS, pH 7.4, 1% BSA, 40% glycerol
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Musashi RNA Binding Protein 2
Introduction
This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells.
Entrez Gene ID
Human124540
Mouse76626
Rat360596
UniProt ID
HumanQ96DH6
MouseQ920Q6
RatF1LWE6
Alternative Names
Musashi RNA Binding Protein 2; Musashi-2; RNA-Binding Protein Musashi Homolog 2; Musashi Homolog 2 (Drosophila); Musashi Homolog 2; MSI2H
Function
RNA binding protein that regulates the expression of target mRNAs at the translation level. May play a role in the proliferation and maintenance of stem cells in the central nervous system (By similarity).
Biological Process
Stem cell development Source: Ensembl
Cellular Location
Cytoplasm
Note: Associated with polysomes.
Involvement in disease
Chromosomal aberrations involving MSI2 may contribute to disease progression in chronic myeloid leukemia. Translocation t(7;17)(p15;q23) with HOXA9; translocation t(7;17)(q32-34;q23).
PTM
Phosphorylated.

Sicking, M., Falke, I., Löblein, M. T., Eich, H. T., Götte, M., Greve, B., & Troschel, F. M. (2023). The Musashi RNA-binding proteins in female cancers: insights on molecular mechanisms and therapeutic relevance. Biomarker Research, 11(1), 76.

Suo, J., Zou, S., Wang, J., Han, Y., Zhang, L., Lv, C., ... & Zou, W. (2022). The RNA-binding protein Musashi2 governs osteoblast-adipocyte lineage commitment by suppressing PPARγ signaling. Bone Research, 10(1), 31.

Wang, J., Lan, L., Wu, X., Xu, L., & Miao, Y. (2022). Mechanism of RNA recognition by a Musashi RNA-binding protein. Current Research in Structural Biology, 4, 10-20.

Löblein, M. T., Falke, I., Eich, H. T., Greve, B., Götte, M., & Troschel, F. M. (2021). Dual knockdown of musashi RNA-binding proteins MSI-1 and MSI-2 attenuates putative cancer stem cell characteristics and therapy resistance in ovarian cancer cells. International Journal of Molecular Sciences, 22(21), 11502.

Sun, J., Sheng, W., Ma, Y., & Dong, M. (2021). Potential role of musashi-2 RNA-binding protein in cancer EMT. OncoTargets and therapy, 1969-1980.

Li, M., Li, A. Q., Zhou, S. L., Lv, H., Wei, P., & Yang, W. T. (2020). RNA-binding protein MSI2 isoforms expression and regulation in progression of triple-negative breast cancer. Journal of Experimental & Clinical Cancer Research, 39, 1-18.

Forouzanfar, M., Lachinani, L., Dormiani, K., Nasr-Esfahani, M. H., Gure, A. O., & Ghaedi, K. (2020). Intracellular functions of RNA-binding protein, Musashi1, in stem and cancer cells. Stem Cell Research & Therapy, 11, 1-10.

Zhao, J., Zhang, Y., Liu, X. S., Zhu, F. M., Xie, F., Jiang, C. Y., ... & Han, B. M. (2020). RNA‐binding protein Musashi2 stabilizing androgen receptor drives prostate cancer progression. Cancer Science, 111(2), 369-382.

Troschel, F. M., Minte, A., Ismail, Y. M., Kamal, A., Abdullah, M. S., Ahmed, S. H., ... & Greve, B. (2020). Knockdown of musashi RNA binding proteins decreases radioresistance but enhances cell motility and invasion in triple-negative breast cancer. International Journal of Molecular Sciences, 21(6), 2169.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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