Human Anti-MUC17 Recombinant Antibody (
8D12) (V2LY-0725-LY1344)

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Tested Data
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Human
Clone
8D12
Application
ELISA
Immunogen
Recombinant Human MUC17 protein.
Host Species
Human
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, Glycerol
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
MUC17
Entrez Gene ID
UniProt ID
Function
Probably plays a role in maintaining homeostasis on mucosal surfaces.
Biological Process
Cellular homeostasis Source: UniProtKB
Cellular Location
Isoform 1:
Plasma membrane
Cell membrane
Isoform 2:
Secreted
Plasma membrane
Cell membrane
Topology
Extracellular: 26-4393
Helical: 4394-4414
Cytoplasmic: 4415-4493
PTM
Probably cleaved within the SEA domain.
N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.

Lin, S., Ruan, H., Qin, L., Zhao, C., Gu, M., Wang, Z., ... & Wang, J. (2023). Acquired resistance to EGFR-TKIs in NSCLC mediates epigenetic downregulation of MUC17 by facilitating NF-κB activity via UHRF1/DNMT1 complex. International Journal of Biological Sciences, 19(3), 832.

Machado, G. C., & Ferrer, V. P. (2023). MUC17 mutations and methylation are associated with poor prognosis in adult-type diffuse glioma patients. Journal of the Neurological Sciences, 452, 120762.

Layunta, E., Jäverfelt, S., Dolan, B., Arike, L., & Pelaseyed, T. (2021). IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during weaning. Cell Reports, 34(7).

Jonckheere, N., Vincent, A., Neve, B., & Van Seuningen, I. (2021). Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkers in epithelial cancers. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1876(1), 188538.

Yang, B., Wu, A., Hu, Y., Tao, C., Wang, J. M., Lu, Y., & Xing, R. (2019). Mucin 17 inhibits the progression of human gastric cancer by limiting inflammatory responses through a MYH9-p53-RhoA regulatory feedback loop. Journal of Experimental & Clinical Cancer Research, 38(1), 1-13.

Lin, S., Zhang, Y., Hu, Y., Yang, B., Cui, J., Huang, J., ... & Lu, Y. (2019). Epigenetic downregulation of MUC17 by H. pylori infection facilitates NF-κB-mediated expression of CEACAM1-3S in human gastric cancer. Gastric Cancer, 22, 941-954.

Schneider, H., Berger, E., Dolan, B., Martinez-Abad, B., Arike, L., Pelaseyed, T., & Hansson, G. C. (2019). The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane. Biochemical Journal, 476(16), 2281-2295.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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