Human Recombinant MUC17 protein, His Tag (V2LY-0526-LY5660)

Name: Human Recombinant MUC17 protein, His Tag
SKU: V2LY-0526-LY5660
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Human

Tag

His Tag

Protein Construction

This product is Human Recombinant MUC17 protein, His Tag consist of Amino Acid: 4131-4390 and predicts a molecular mass of 30.7 kDa.

Molecule Mass

30.7 kDa

Verified

HPLC

Sequence

Amino Acid: 4131-4390

Species

Human

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

≥95% as determined by SDS-PAGE. ≥95% as determined by SEC-HPLC.

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

MUC17

Function

Probably plays a role in maintaining homeostasis on mucosal surfaces.

Biological Process

Cellular homeostasis Source: UniProtKB

Cellular Location

Isoform 1:
Plasma membrane
Cell membrane
Isoform 2:
Secreted
Plasma membrane
Cell membrane

Topology

Extracellular: 26-4393
Helical: 4394-4414
Cytoplasmic: 4415-4493

PTM

Probably cleaved within the SEA domain.
N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.

Lin, S., Ruan, H., Qin, L., Zhao, C., Gu, M., Wang, Z., ... & Wang, J. (2023). Acquired resistance to EGFR-TKIs in NSCLC mediates epigenetic downregulation of MUC17 by facilitating NF-κB activity via UHRF1/DNMT1 complex. International Journal of Biological Sciences, 19(3), 832.

Machado, G. C., & Ferrer, V. P. (2023). MUC17 mutations and methylation are associated with poor prognosis in adult-type diffuse glioma patients. Journal of the Neurological Sciences, 452, 120762.

Layunta, E., Jäverfelt, S., Dolan, B., Arike, L., & Pelaseyed, T. (2021). IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during weaning. Cell Reports, 34(7).

Jonckheere, N., Vincent, A., Neve, B., & Van Seuningen, I. (2021). Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkers in epithelial cancers. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1876(1), 188538.

Yang, B., Wu, A., Hu, Y., Tao, C., Wang, J. M., Lu, Y., & Xing, R. (2019). Mucin 17 inhibits the progression of human gastric cancer by limiting inflammatory responses through a MYH9-p53-RhoA regulatory feedback loop. Journal of Experimental & Clinical Cancer Research, 38(1), 1-13.

Lin, S., Zhang, Y., Hu, Y., Yang, B., Cui, J., Huang, J., ... & Lu, Y. (2019). Epigenetic downregulation of MUC17 by H. pylori infection facilitates NF-κB-mediated expression of CEACAM1-3S in human gastric cancer. Gastric Cancer, 22, 941-954.

Schneider, H., Berger, E., Dolan, B., Martinez-Abad, B., Arike, L., Pelaseyed, T., & Hansson, G. C. (2019). The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane. Biochemical Journal, 476(16), 2281-2295.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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