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Mouse Anti-MUC17 Antibody (9BA6) (CBMAB-1432CQ)

This product is a mouse antibody that recognizes MUC17. The antibody 9BA6 can be used for immunoassay techniques such as: ELISA, WB.
See all MUC17 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
9BA6
Antibody Isotype
IgG2c
Application
ELISA, WB

Basic Information

Immunogen
Recombinant full length protein (aa 4015-4389)
Specificity
Human
Antibody Isotype
IgG2c
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Supernatant
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
MUC17
Introduction
The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Diseases associated with MUC17 include Biliary Papillomatosis and Colorectal Cancer 1. Among its related pathways are O-linked glycosylation and HIV Life Cycle.
Entrez Gene ID
140453
UniProt ID
Q685J3
Alternative Names
MUC3; MUC-3; MUC-17
Function
Probably plays a role in maintaining homeostasis on mucosal surfaces.
Biological Process
Cellular homeostasis Source: UniProtKB
Cellular Location
Isoform 1:
Plasma membrane
Cell membrane
Isoform 2:
Secreted
Plasma membrane
Cell membrane
Topology
Extracellular: 26-4393
Helical: 4394-4414
Cytoplasmic: 4415-4493
PTM
Probably cleaved within the SEA domain.
N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.

Lin, S., Ruan, H., Qin, L., Zhao, C., Gu, M., Wang, Z., ... & Wang, J. (2023). Acquired resistance to EGFR-TKIs in NSCLC mediates epigenetic downregulation of MUC17 by facilitating NF-κB activity via UHRF1/DNMT1 complex. International Journal of Biological Sciences, 19(3), 832.

Machado, G. C., & Ferrer, V. P. (2023). MUC17 mutations and methylation are associated with poor prognosis in adult-type diffuse glioma patients. Journal of the Neurological Sciences, 452, 120762.

Layunta, E., Jäverfelt, S., Dolan, B., Arike, L., & Pelaseyed, T. (2021). IL-22 promotes the formation of a MUC17 glycocalyx barrier in the postnatal small intestine during weaning. Cell Reports, 34(7).

Jonckheere, N., Vincent, A., Neve, B., & Van Seuningen, I. (2021). Mucin expression, epigenetic regulation and patient survival: A toolkit of prognostic biomarkers in epithelial cancers. Biochimica et Biophysica Acta (BBA)-Reviews on Cancer, 1876(1), 188538.

Yang, B., Wu, A., Hu, Y., Tao, C., Wang, J. M., Lu, Y., & Xing, R. (2019). Mucin 17 inhibits the progression of human gastric cancer by limiting inflammatory responses through a MYH9-p53-RhoA regulatory feedback loop. Journal of Experimental & Clinical Cancer Research, 38(1), 1-13.

Lin, S., Zhang, Y., Hu, Y., Yang, B., Cui, J., Huang, J., ... & Lu, Y. (2019). Epigenetic downregulation of MUC17 by H. pylori infection facilitates NF-κB-mediated expression of CEACAM1-3S in human gastric cancer. Gastric Cancer, 22, 941-954.

Schneider, H., Berger, E., Dolan, B., Martinez-Abad, B., Arike, L., Pelaseyed, T., & Hansson, G. C. (2019). The human transmembrane mucin MUC17 responds to TNFα by increased presentation at the plasma membrane. Biochemical Journal, 476(16), 2281-2295.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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