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MUC17

The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene.

Full Name

MUC17

Function

Probably plays a role in maintaining homeostasis on mucosal surfaces.

Biological Process

Cellular homeostasis Source: UniProtKB

Cellular Location

Isoform 1:
Plasma membrane
Cell membrane
Isoform 2:
Secreted
Plasma membrane
Cell membrane

Topology

Extracellular: 26-4393
Helical: 4394-4414
Cytoplasmic: 4415-4493

PTM

Probably cleaved within the SEA domain.
N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.

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Anti-MUC17 antibodies

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Mouse Anti-MUC17 Antibody (9BA7) (CBMAB-1433CQ)

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Target: MUC17

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 9BA7

Application*: E, WB

Recombinant Mouse Anti-MUC17 Recombinant Antibody (NCRC74) (CBMAB-XB0848-YC)

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Target: MUC17

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: NCRC74

Application*: E

Recombinant Mouse Anti-MUC17 Recombinant Antibody (1143/B7) (CBMAB-XB0847-YC)

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Target: MUC17

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human

Clone: 1143/B7

Application*: E, IH

Recombinant Mouse Anti-MUC17 Recombinant Antibody (1175) (CBMAB-XB0846-YC)

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Target: MUC17

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1175

Application*: E, F, IH

Mouse Anti-MUC17 Recombinant Antibody (CBFYM-2798) (CBMAB-M2991-FY)

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Target: MUC17

Host: Mouse

Specificity: Human

Clone: CBFYM-2798

Application*: WB, IC, P, C, E

Mouse Anti-MUC17 Antibody (9BA6) (CBMAB-1432CQ)

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Target: MUC17

Host: Mouse

Antibody Isotype: IgG2c

Specificity: Human

Clone: 9BA6

Application*: E, WB

Human Recombinant MUC17 protein, His Tag (V2LY-0526-LY5660)

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Target: MUC17

Expressed Host: HEK293 Cells

Sequence: Amino Acid: 4131-4390

Tag: His Tag

Human Anti-MUC17 Recombinant Antibody (
8D12) (V2LY-0725-LY1344)

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Target: MUC17

Host: Human

Antibody Isotype: IgG

Specificity: Human

Clone: 8D12

Application*: E

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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