MUC17

The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene.
Full Name
MUC17
Function
Probably plays a role in maintaining homeostasis on mucosal surfaces.
Biological Process
Cellular homeostasis Source: UniProtKB
Cellular Location
Isoform 1:
Plasma membrane
Cell membrane
Isoform 2:
Secreted
Plasma membrane
Cell membrane
Topology
Extracellular: 26-4393
Helical: 4394-4414
Cytoplasmic: 4415-4493
PTM
Probably cleaved within the SEA domain.
N-glycosylated. Contains high mannose and complex-type glycans. The forms containing the complex type glycans localize to the cell surface. Not O-glycosylated.
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Anti-MUC17 antibodies

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Mouse Anti-MUC17 Antibody (9BA7) (CBMAB-1433CQ)

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Target: MUC17
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 9BA7
Application*: E, WB
Datasheet SDS

Recombinant Mouse Anti-MUC17 Recombinant Antibody (NCRC74) (CBMAB-XB0848-YC)

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Target: MUC17
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: NCRC74
Application*: E
Datasheet SDS

Recombinant Mouse Anti-MUC17 Recombinant Antibody (1143/B7) (CBMAB-XB0847-YC)

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Target: MUC17
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1143/B7
Application*: E, IH
Datasheet SDS

Recombinant Mouse Anti-MUC17 Recombinant Antibody (1175) (CBMAB-XB0846-YC)

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Target: MUC17
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1175
Application*: E, F, IH
Datasheet SDS

Mouse Anti-MUC17 Recombinant Antibody (CBFYM-2798) (CBMAB-M2991-FY)

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Target: MUC17
Host: Mouse
Specificity: Human
Clone: CBFYM-2798
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-MUC17 Antibody (9BA6) (CBMAB-1432CQ)

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Target: MUC17
Host: Mouse
Antibody Isotype: IgG2c
Specificity: Human
Clone: 9BA6
Application*: E, WB
Datasheet SDS

Human Anti-MUC17 Recombinant Antibody (
8D12) (V2LY-0725-LY1344)

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Target: MUC17
Host: Human
Antibody Isotype: IgG
Specificity: Human
Clone: 8D12
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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