Sign in or Register   Sign in or Register
  |  

Mouse Anti-NUDT1 Recombinant Antibody (5F11) (CBMAB-N3863-WJ)

This product is a Mouse antibody that recognizes NUDT1. The antibody 5F11 can be used for immunoassay techniques such as: ELISA, WB.
See all NUDT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5F11
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Nudix Hydrolase 1
Introduction
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008]
Entrez Gene ID
UniProt ID
Alternative Names
Nudix Hydrolase 1; Nudix Motif 1; 8-Oxo-DGTPase; Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1; Nucleoside Diphosphate-Linked Moiety X-Type Motif 1; 8-Oxo-7,8-Dihydrodeoxyguanosine Triphosphatase; Nucleoside Diphosphate-Linked Moiety X Motif 1; 8-Oxo-7,8-Dihydroguanosine Triphosphatase;
Function
Oxidized purine nucleoside triphosphate hydrolase which is a prominent sanitizer of the oxidized nucleotide pool (PubMed:8226881, PubMed:7713500, PubMed:10608900, PubMed:12857738, PubMed:22556419, PubMed:26238318, PubMed:24695224, PubMed:24695225, PubMed:28679043).
Catalyzes the hydrolysis of 2-oxo-dATP (2-hydroxy-dATP) into 2-oxo-dAMP (PubMed:10373420).
Has also a significant hydrolase activity toward 2-oxo-ATP, 8-oxo-dGTP and 8-oxo-dATP (PubMed:10373420, PubMed:11139615).
Through the hydrolysis of oxidized purine nucleoside triphosphates, prevents their incorporation into DNA and the subsequent transversions A:T to C:G and G:C to T:A (PubMed:8226881, PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004).
Also catalyzes the hydrolysis of methylated purine nucleoside triphosphate preventing their integration into DNA (PubMed:30304478, PubMed:32144205).
Through this antimutagenic activity protects cells from oxidative stress (PubMed:8226881, PubMed:7713500, PubMed:10608900, PubMed:12857738, PubMed:24695224, PubMed:24695225, PubMed:30304478, PubMed:32144205).
Biological Process
AgingIEA:Ensembl
DNA protectionManual Assertion Based On ExperimentIDA:UniProtKB
DNA repair1 PublicationIC:UniProtKB
Male gonad developmentIEA:Ensembl
Purine nucleoside catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Response to cadmium ionIEA:Ensembl
Response to oxidative stressManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Isoform p18
Cytoplasm, cytosol
Mitochondrion matrix
Nucleus
Mostly present in cytosol (PubMed:7782328).
A minor proportion is mitochondrial (PubMed:7782328).
A very small amount of the protein is associated with nuclei (PubMed:7782328).
Isoform p26
Mitochondrion matrix
PTM
The N-terminus is blocked.
Ask a question We look forward to hearing from you.
0 reviews or Q&As
Loading...
Have you used Mouse Anti-NUDT1 Recombinant Antibody (5F11)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare