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NUDT1 Matched Antibody Pair (824) (APMAB-824LY)

This antibody pair set can be used for detecting and quantifying protein level of human NUDT1.
See all NUDT1 antibodies

Specifications

ApplIcation
Sandwich ELISA
Specificity
Human
Capture Antibody
Rabbit anti-NUDT1 polyclonal antibody, 100 ug
Detection Antibody
Anti-NUDT1 Mouse monoclonal, IgG2a antibody, 20 ug
Dilutions
10 ng/ml-100 ng/ml
Format
Liquid
Storage
Aliquot and store at -20°Cor -80°C. Avoid freeze-thaw cycles.
Introduction
Misincorporation of oxidized nucleoside triphosphates into DNA/RNA during replication and transcription can cause mutations that may result in carcinogenesis or neurodegeneration. The protein encoded by this gene is an enzyme that hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP, 8-oxo-dATP, 2-hydroxy-dATP, and 2-hydroxy rATP, to monophosphates, thereby preventing misincorporation. The encoded protein is localized mainly in the cytoplasm, with some in the mitochondria, suggesting that it is involved in the sanitization of nucleotide pools both for nuclear and mitochondrial genomes. Several alternatively spliced transcript variants, some of which encode distinct isoforms, have been identified. Additional variants have been observed, but their full-length natures have not been determined. A single-nucleotide polymorphism that results in the production of an additional, longer isoform (p26) has been described. [provided by RefSeq, Jul 2008]
Alternative Names
Nudix Hydrolase 1; Nudix Motif 1; 8-Oxo-DGTPase; Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 1; Nucleoside Diphosphate-Linked Moiety X-Type Motif 1; 8-Oxo-7,8-Dihydrodeoxyguanosine Triphosphatase; Nucleoside Diphosphate-Linked Moiety X Motif 1; 8-Oxo-7,8-Dihydroguanosine Triphosphatase;
Entrez Gene ID
4521
UniProt ID
P36639

Lau, H. C., Yuan, X., Huang, H., Zhang, M., Hsueh, C. Y., & Gong, H. (2023). Fusobacterium nucleatum facilitates proliferation and autophagy by activating miR-361-3p/NUDT1 axis through oxidative stress in hypopharyngeal squamous cell carcinoma. BMC cancer, 23(1), 990.

Lin, Y., Zhang, F., Jin, Y., Zhong, Q., Tan, W., Liu, J., & Wu, Z. (2022). NUDT1 could be a prognostic biomarker and correlated with immune infiltration in clear cell renal cell carcinoma. Applied bionics and biomechanics, 2022.

Huang, B., Lyu, Z., Qian, Q., Chen, Y., Zhang, J., Li, B., ... & Ma, X. (2022). NUDT1 promotes the accumulation and longevity of CD103+ TRM cells in primary biliary cholangitis. Journal of hepatology, 77(5), 1311-1324.

Shi, J., Xiong, Z., Wang, K., Yuan, C., Huang, Y., Xiao, W., ... & Zhang, X. (2021). HIF2α promotes tumour growth in clear cell renal cell carcinoma by increasing the expression of NUDT1 to reduce oxidative stress. Clinical and translational medicine, 11(11), e592.

Bialkowski, K., & Szpila, A. (2021). Specific 8-oxo-dGTPase activity of MTH1 (NUDT1) protein as a quantitative marker and prognostic factor in human colorectal cancer. Free Radical Biology and Medicine, 176, 257-264.

Vitry, G., Paulin, R., Grobs, Y., Lampron, M. C., Shimauchi, T., Lemay, S. E., ... & Bonnet, S. (2021). Oxidized DNA precursors cleanup by NUDT1 contributes to vascular remodeling in pulmonary arterial hypertension. American Journal of Respiratory and Critical Care Medicine, 203(5), 614-627.

Agarwal, S., & de Jesus Perez, V. A. (2021). In defense of the Nucleus: NUDT1 and oxidative DNA damage in pulmonary arterial Hypertension. American Journal of Respiratory and Critical Care Medicine, 203(5), 541-542.

Shen, Y., Zhang, L., Piao, S., Li, L., Li, J., Xia, Y., ... & Saiyin, W. (2020). NUDT1: A potential independent predictor for the prognosis of patients with oral squamous cell carcinoma. Journal of Oral Pathology & Medicine, 49(3), 210-218.

Bialkowski, K., & Kasprzak, K. S. (2020). A profile of 8-oxo-dGTPase activities in the NCI-60 human cancer panel: meta-analytic insight into the regulation and role of MTH1 (NUDT1) gene expression in carcinogenesis. Free Radical Biology and Medicine, 148, 1-21.

Tahara, Y. K., Kietrys, A. M., Hebenbrock, M., Lee, Y., Wilson, D. L., & Kool, E. T. (2019). Dual inhibitors of 8-oxoguanine surveillance by OGG1 and NUDT1. ACS chemical biology, 14(12), 2606-2615.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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