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Mouse Anti-PAPPA2 Recombinant Antibody (242011) (CBMAB-P0759-YC)

Provided herein is a Mouse monoclonal antibody against Human Pappalysin 2. The antibody can be used for immunoassay techniques, such as WB, IP.
See all PAPPA2 antibodies
Published Data
Fig.1 Semi-quantitative western blot analysis of PAPPA2.
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Fig.2 Maternal deciduas. A subset of cells, invasive cytotrophoblasts or stromal cells of deciduas, was found to be positive for PAPP-A2.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
242011
Antibody Isotype
IgG2b
Application
WB, IP

Basic Information

Immunogen
Mouse myeloma cell line NS0-derived Recombinant human Pappalysin-2/PAPP-A2, Ser234-Cys1396
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized from PBS with trehalose
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Pappalysin 2
Introduction
PAPPA2 is a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability.
Entrez Gene ID
60676
UniProt ID
Q9BXP8
Alternative Names
Pappalysin 2; Pregnancy-Associated Plasma Protein E1; Placenta-Specific 3; PAPP-A2; PAPP-E; PLAC3;
Function
Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3.
Biological Process
Bone morphogenesisIEA:Ensembl
Cellular protein metabolic processTAS:Reactome
ProteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell growth1 PublicationNAS:UniProtKB
Response to salt stressIEA:Ensembl
Cellular Location
Secreted
Involvement in disease
Short stature, Dauber-Argente type (SSDA):
An autosomal recessive disorder characterized by progressive postnatal growth failure, moderate microcephaly, thin long bones, mildly decreased bone density, and elevated serum levels of total IGF1, IGFBP3 and IGFBP5. Levels of circulating free IGF1 are reduced.

Xie, Q., Zhang, Z., Chen, Z., Sun, J., Li, M., Wang, Q., & Pan, Y. (2023). Integration of selection signatures and protein interactions reveals NR6A1, PAPPA2, and PIK3C2B as the promising candidate genes underlying the characteristics of licha black pig. Biology, 12(4), 500.

Upners, E. N., Ljubicic, M. L., Busch, A. S., Fischer, M. B., Almstrup, K., Petersen, J. H., ... & Juul, A. (2022). Dynamic changes in serum IGF-I and growth during infancy: associations to body fat, target height, and PAPPA2 genotype. The Journal of Clinical Endocrinology & Metabolism, 107(1), 219-229.

Dong, Y., Zhao, L., Duan, J., Bai, H., Chen, D., Li, S., ... & Wang, Z. (2022). PAPPA2 mutation as a novel indicator stratifying beneficiaries of immune checkpoint inhibitors in skin cutaneous melanoma and non‐small cell lung cancer. Cell Proliferation, 55(9), e13283.

Qin, M., Liang, Z., Qin, H., Huo, Y., Wu, Q., Yang, H., & Tang, G. (2021). Novel prognostic biomarkers in gastric cancer: CGB5, MKNK2, and PAPPA2. Frontiers in oncology, 11, 683582.

Rubio, L., Vargas, A., Rivera, P., López-Gambero, A. J., Tovar, R., Christians, J. K., ... & Suárez, J. (2021). Recombinant IGF-1 induces sex-specific changes in bone composition and remodeling in adult mice with Pappa2 deficiency. International Journal of Molecular Sciences, 22(8), 4048.

Harsanyi, S., Zamborsky, R., Krajciova, L., Kokavec, M., & Danisovic, L. (2021). Genetic study of IL6, GDF5 and PAPPA2 in association with developmental dysplasia of the hip. Genes, 12(7), 986.

Barrios, V., Chowen, J. A., Martín-Rivada, Á., Guerra-Cantera, S., Pozo, J., Yakar, S., ... & Argente, J. (2021). Pregnancy-associated plasma protein (PAPP)-A2 in physiology and disease. Cells, 10(12), 3576.

Fujimoto, M., Andrew, M., & Dauber, A. (2020). Disorders caused by genetic defects associated with GH-dependent genes: PAPPA2 defects. Molecular and cellular endocrinology, 518, 110967.

Christians, J. K., Amiri, N., Schipilow, J. D., Zhang, S. W., & May-Rashke, K. I. (2019). Pappa2 deletion has sex-and age-specific effects on bone in mice. Growth Hormone & IGF Research, 44, 6-10.

Chen, Y., Li, L., Wang, E., Zhang, L., & Zhao, Q. (2019). Abnormal expression of Pappa2 gene may indirectly affect mouse hip development through the IGF signaling pathway. Endocrine, 65, 440-450.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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