Mouse Anti-PAPPA2 Recombinant Antibody (8M12) (CBMAB-P0760-YC)

Name: Mouse Anti-PAPPA2 Recombinant Antibody (8M12)
SKU: CBMAB-P0760-YC
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

8M12

Application

Immunogen

Human recombinant Pappalysin-2

Specificity

Human

Antibody Isotype

IgG2

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized from PBS

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Pappalysin 2

Introduction

PAPPA2 is a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability.

Entrez Gene ID

60676

UniProt ID

Q9BXP8

Alternative Names

Pappalysin 2; Pregnancy-Associated Plasma Protein E1; Placenta-Specific 3; PAPP-A2; PAPP-E; PLAC3;

Function

Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3.

Biological Process

Bone morphogenesisIEA:Ensembl
Cellular protein metabolic processTAS:Reactome
ProteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell growth1 PublicationNAS:UniProtKB
Response to salt stressIEA:Ensembl

Cellular Location

Secreted

Involvement in disease

Short stature, Dauber-Argente type (SSDA):
An autosomal recessive disorder characterized by progressive postnatal growth failure, moderate microcephaly, thin long bones, mildly decreased bone density, and elevated serum levels of total IGF1, IGFBP3 and IGFBP5. Levels of circulating free IGF1 are reduced.

Xie, Q., Zhang, Z., Chen, Z., Sun, J., Li, M., Wang, Q., & Pan, Y. (2023). Integration of selection signatures and protein interactions reveals NR6A1, PAPPA2, and PIK3C2B as the promising candidate genes underlying the characteristics of licha black pig. Biology, 12(4), 500.

Upners, E. N., Ljubicic, M. L., Busch, A. S., Fischer, M. B., Almstrup, K., Petersen, J. H., ... & Juul, A. (2022). Dynamic changes in serum IGF-I and growth during infancy: associations to body fat, target height, and PAPPA2 genotype. The Journal of Clinical Endocrinology & Metabolism, 107(1), 219-229.

Dong, Y., Zhao, L., Duan, J., Bai, H., Chen, D., Li, S., ... & Wang, Z. (2022). PAPPA2 mutation as a novel indicator stratifying beneficiaries of immune checkpoint inhibitors in skin cutaneous melanoma and non‐small cell lung cancer. Cell Proliferation, 55(9), e13283.

Qin, M., Liang, Z., Qin, H., Huo, Y., Wu, Q., Yang, H., & Tang, G. (2021). Novel prognostic biomarkers in gastric cancer: CGB5, MKNK2, and PAPPA2. Frontiers in oncology, 11, 683582.

Rubio, L., Vargas, A., Rivera, P., López-Gambero, A. J., Tovar, R., Christians, J. K., ... & Suárez, J. (2021). Recombinant IGF-1 induces sex-specific changes in bone composition and remodeling in adult mice with Pappa2 deficiency. International Journal of Molecular Sciences, 22(8), 4048.

Harsanyi, S., Zamborsky, R., Krajciova, L., Kokavec, M., & Danisovic, L. (2021). Genetic study of IL6, GDF5 and PAPPA2 in association with developmental dysplasia of the hip. Genes, 12(7), 986.

Barrios, V., Chowen, J. A., Martín-Rivada, Á., Guerra-Cantera, S., Pozo, J., Yakar, S., ... & Argente, J. (2021). Pregnancy-associated plasma protein (PAPP)-A2 in physiology and disease. Cells, 10(12), 3576.

Fujimoto, M., Andrew, M., & Dauber, A. (2020). Disorders caused by genetic defects associated with GH-dependent genes: PAPPA2 defects. Molecular and cellular endocrinology, 518, 110967.

Christians, J. K., Amiri, N., Schipilow, J. D., Zhang, S. W., & May-Rashke, K. I. (2019). Pappa2 deletion has sex-and age-specific effects on bone in mice. Growth Hormone & IGF Research, 44, 6-10.

Chen, Y., Li, L., Wang, E., Zhang, L., & Zhao, Q. (2019). Abnormal expression of Pappa2 gene may indirectly affect mouse hip development through the IGF signaling pathway. Endocrine, 65, 440-450.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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