PAPPA2

PAPPA2 is a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability.

Full Name

Pappalysin 2

Function

Metalloproteinase which specifically cleaves insulin-like growth factor binding protein (IGFBP)-5 at the '163-Ser-|-Lys-164' bond. Shows limited proteolysis toward IGFBP-3.

Biological Process

Bone morphogenesisIEA:Ensembl
Cellular protein metabolic processTAS:Reactome
ProteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell growth1 PublicationNAS:UniProtKB
Response to salt stressIEA:Ensembl

Cellular Location

Secreted

Involvement in disease

Short stature, Dauber-Argente type (SSDA):
An autosomal recessive disorder characterized by progressive postnatal growth failure, moderate microcephaly, thin long bones, mildly decreased bone density, and elevated serum levels of total IGF1, IGFBP3 and IGFBP5. Levels of circulating free IGF1 are reduced.

Anti-PAPPA2 antibodies

Mouse Anti-PAPPA2 Recombinant Antibody (242011) (CBMAB-P0759-YC)

Datasheet

SDS

Target: PAPPA2

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 242011

Application*: WB, IP

Mouse Anti-PAPPA2 Recombinant Antibody (8M12) (CBMAB-P0760-YC)

Datasheet

SDS

Target: PAPPA2

Host: Mouse

Antibody Isotype: IgG2

Specificity: Human

Clone: 8M12

Application*: WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)