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Mouse Anti-PGAM1 Recombinant Antibody (2G1-A6) (CBMAB-P1544-YC)

Provided herein is a Mouse monoclonal antibody against Human Phosphoglycerate Mutase 1. The antibody can be used for immunoassay techniques, such as ELISA, IP, WB.
See all PGAM1 antibodies
Published Data
Fig.1 PGAM1 inhibition sensitizes BRCA-proficient breast cancer toward PARP inhibitors.
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Fig.2 Western blot analysis of CRABP2, CALR, LUM, PRDX1, PGAM1, ANXA2 and ALDOA in paired MIF and LIF.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2G1-A6
Antibody Isotype
IgG1, κ
Application
ELISA, IP, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid in PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phosphoglycerate Mutase 1
Introduction
PGAM1 is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway.
Entrez Gene ID
5223
UniProt ID
P18669
Alternative Names
Phosphoglycerate Mutase 1; Phosphoglycerate Mutase A, Nonmuscle Form; Phosphoglycerate Mutase 1 (Brain); Phosphoglycerate Mutase Isozyme B; BPG-Dependent PGAM 1; PGAM-B; PGAMA;
Function
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202).
Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202).
Biological Process
Glycolytic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of glycolytic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of pentose-phosphate shuntManual Assertion Based On ExperimentIDA:UniProtKB
Respiratory burstManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
cytoplasm
cytosol
extracellular exosome
extracellular region
ficolin-1-rich granule lumen
membrane
secretory granule lumen
PTM
Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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