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Rabbit Anti-PGAM1 Recombinant Antibody (CBYC-P316) (CBMAB-P1545-YC)

Provided herein is a Rabbit monoclonal antibody against Human Phosphoglycerate Mutase 1. The antibody can be used for immunoassay techniques, such as WB, FC.
See all PGAM1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBYC-P316
Antibody Isotype
IgG
Application
WB, FC

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Phosphoglycerate Mutase 1
Introduction
PGAM1 is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway.
Entrez Gene ID
Human5223
Mouse18648
Rat24642
UniProt ID
HumanP18669
MouseQ9DBJ1
RatP25113
Alternative Names
Phosphoglycerate Mutase 1; Phosphoglycerate Mutase A, Nonmuscle Form; Phosphoglycerate Mutase 1 (Brain); Phosphoglycerate Mutase Isozyme B; BPG-Dependent PGAM 1; PGAM-B; PGAMA;
Function
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202).
Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202).
Biological Process
Glycolytic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of glycolytic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of pentose-phosphate shuntManual Assertion Based On ExperimentIDA:UniProtKB
Respiratory burstManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
cytoplasm
cytosol
extracellular exosome
extracellular region
ficolin-1-rich granule lumen
membrane
secretory granule lumen
PTM
Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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