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PGAM1

The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]
Full Name
Phosphoglycerate Mutase 1
Function
Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202).
Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202).
Biological Process
Glycolytic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of glycolytic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of pentose-phosphate shuntManual Assertion Based On ExperimentIDA:UniProtKB
Respiratory burstManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
cytoplasm
cytosol
extracellular exosome
extracellular region
ficolin-1-rich granule lumen
membrane
secretory granule lumen
PTM
Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme.
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Anti-PGAM1 antibodies

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Rabbit Anti-PGAM1 Recombinant Antibody (D3J9T) (CBMAB-CP1943-LY)

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Target: PGAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Hamster, Monkey
Clone: D3J9T
Application*: WB
Datasheet SDS

Mouse Anti-PGAM1 Recombinant Antibody (4F5-D8) (CBMAB-A6595-LY)

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Target: PGAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4F5-D8
Application*: IP, E
Datasheet SDS

Rabbit Anti-PGAM1 Recombinant Antibody (CBYC-P316) (CBMAB-P1545-YC)

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Target: PGAM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBYC-P316
Application*: WB, F
Datasheet SDS

Mouse Anti-PGAM1 Recombinant Antibody (2G1-A6) (CBMAB-P1544-YC)

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Target: PGAM1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2G1-A6
Application*: E, IP, WB
Datasheet SDS

Mouse Anti-PGAM1 Recombinant Antibody (1G4) (CBMAB-P1543-YC)

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Target: PGAM1
Host: Mouse
Antibody Isotype: IgG2a, λ
Specificity: Human
Clone: 1G4
Application*: WB, F, E, IC, IF
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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