PGAM1

The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Full Name

Phosphoglycerate Mutase 1

Function

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202).
Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202).

Biological Process

Glycolytic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of glycolytic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of pentose-phosphate shuntManual Assertion Based On ExperimentIDA:UniProtKB
Respiratory burstManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

cytoplasm
cytosol
extracellular exosome
extracellular region
ficolin-1-rich granule lumen
membrane
secretory granule lumen

PTM

Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme.

Anti-PGAM1 antibodies

Rabbit Anti-PGAM1 Recombinant Antibody (D3J9T) (CBMAB-CP1943-LY)

Datasheet

SDS

Target: PGAM1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Hamster, Monkey

Clone: D3J9T

Application*: WB

Mouse Anti-PGAM1 Recombinant Antibody (4F5-D8) (CBMAB-A6595-LY)

Datasheet

SDS

Target: PGAM1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4F5-D8

Application*: IP, E

Rabbit Anti-PGAM1 Recombinant Antibody (CBYC-P316) (CBMAB-P1545-YC)

Datasheet

SDS

Target: PGAM1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBYC-P316

Application*: WB, F

Mouse Anti-PGAM1 Recombinant Antibody (2G1-A6) (CBMAB-P1544-YC)

Datasheet

SDS

Target: PGAM1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2G1-A6

Application*: E, IP, WB

Mouse Anti-PGAM1 Recombinant Antibody (1G4) (CBMAB-P1543-YC)

Datasheet

SDS

Target: PGAM1

Host: Mouse

Antibody Isotype: IgG2a, λ

Specificity: Human

Clone: 1G4

Application*: WB, F, E, IC, IF

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)