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PGAM1

The protein encoded by this gene is a mutase that catalyzes the reversible reaction of 3-phosphoglycerate (3-PGA) to 2-phosphoglycerate (2-PGA) in the glycolytic pathway. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Full Name

Phosphoglycerate Mutase 1

Function

Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglyceratea crucial step in glycolysis, by using 2,3-bisphosphoglycerate (PubMed:23653202).
Also catalyzes the interconversion of (2R)-2,3-bisphosphoglycerate and (2R)-3-phospho-glyceroyl phosphate (PubMed:23653202).

Biological Process

Glycolytic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of glycolytic processManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of pentose-phosphate shuntManual Assertion Based On ExperimentIDA:UniProtKB
Respiratory burstManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

cytoplasm
cytosol
extracellular exosome
extracellular region
ficolin-1-rich granule lumen
membrane
secretory granule lumen

PTM

Acetylated at Lys-253, Lys-253 and Lys-254 under high glucose condition. Acetylation increases catalytic activity. Under glucose restriction SIRT1 levels dramatically increase and it deacetylates the enzyme.

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Anti-PGAM1 antibodies

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Rabbit Anti-PGAM1 Recombinant Antibody (D3J9T) (CBMAB-CP1943-LY)

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Target: PGAM1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Hamster, Monkey

Clone: D3J9T

Application*: WB

Mouse Anti-PGAM1 Recombinant Antibody (4F5-D8) (CBMAB-A6595-LY)

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Target: PGAM1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 4F5-D8

Application*: IP, E

Rabbit Anti-PGAM1 Recombinant Antibody (CBYC-P316) (CBMAB-P1545-YC)

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Target: PGAM1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: CBYC-P316

Application*: WB, F

Mouse Anti-PGAM1 Recombinant Antibody (2G1-A6) (CBMAB-P1544-YC)

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Target: PGAM1

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 2G1-A6

Application*: E, IP, WB

Mouse Anti-PGAM1 Recombinant Antibody (1G4) (CBMAB-P1543-YC)

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Target: PGAM1

Host: Mouse

Antibody Isotype: IgG2a, λ

Specificity: Human

Clone: 1G4

Application*: WB, F, E, IC, IF

Rabbit Anti-PGAM1 Recombinant Antibody (
9A5) (V2LY-0725-LY1494)

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Target: PGAM1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: 9A5

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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